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ALAS1 and TTC23
Data Source:
BioGRID
(two hybrid)
ALAS1
TTC23
Description
5'-aminolevulinate synthase 1
tetratricopeptide repeat domain 23
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Cilium
Molecular Function
5-aminolevulinate Synthase Activity
Protein Binding
Pyridoxal Phosphate Binding
Identical Protein Binding
Protein Binding
Biological Process
Response To Hypoxia
Protoporphyrinogen IX Biosynthetic Process
Heme Biosynthetic Process
Mitochondrion Organization
Regulation Of Lipid Metabolic Process
Hemoglobin Biosynthetic Process
Erythrocyte Development
Positive Regulation Of Smoothened Signaling Pathway
Pathways
Heme biosynthesis
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Drugs
Pyridoxal phosphate
Pyridoxal phosphate
Glycine
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
)
Parkinson's disease (
28892059
)
Schizophrenia (
23974872
)
Interacting Genes
54 interacting genes:
BCL7A
C2orf42
C8orf33
CAP2
CCHCR1
CDC73
CDK5
CDKN1A
CERK
COBL
DUSP19
EP400
FBXL8
GNL3L
GRXCR1
HSBP1L1
JRK
KIF9
KLHL35
LONRF1
LRRC45
MTFR2
MTSS2
NUDT3
OXTR
PIBF1
PIK3CB
PLAU
POLDIP2
PPL
RAP1B
RNF168
RTL8B
SH2D4A
SNRPB2
SNX20
STAMBP
SUMO2
TCEA2
TEKT4
TK1
TMSB10
TMSB4X
TMSB4XP1
TMSB4XP2
TMSB4XP6
TTC23
USP20
UTP14C
WIPF1
ZFYVE26
ZMAT1
ZNF175
ZNF564
99 interacting genes:
ABI1
ADCY4
ALAS1
APP
BANP
BHLHE40
BLZF1
C1orf109
CBX8
CCDC102B
CCDC24
CCNDBP1
CDK18
CDR2
CNTROB
CREBZF
CYSRT1
DISC1
EFCAB3
FAM161B
FSD2
GOLGA2
GOLGA6L9
GPANK1
GPRASP2
GRIPAP1
HOOK2
HSF2BP
HTT
INSC
IQCE
KASH5
KDM1A
KIAA1328
KLHL42
KRT15
KRT16
KRT27
KRT31
KRT34
KRT36
KRT40
KRTAP10-3
KRTAP10-8
LCN2
LDOC1
LZTS2
MAGED1
MBD3
MDFI
MED12L
MESD
MID2
MKRN3
MTUS2
NOTO
NUTM1
PICK1
PIH1D2
PLEKHG4
PNMA1
PNMA5
POLR2J3
POU6F2
PPP1R16A
PRDM6
PRKAB2
PRPH
PSORS1C2
RAD51D
RBCK1
SPAG11B
SPAG5
SPAG8
SPDEF
SSX2IP
TADA2A
TEX13A
TLE5
TRAF2
TRAPPC6A
TRIB3
TRIM10
TRIM32
TRIM54
TRIM73
TRIP6
TSGA10IP
UBXN11
USHBP1
XIAP
XRN2
ZBED1
ZBTB16
ZBTB42
ZDHHC17
ZFHX3
ZFYVE26
ZIM2
Entrez ID
211
64927
HPRD ID
00505
07777
Ensembl ID
ENSG00000023330
ENSG00000103852
Uniprot IDs
B4DVA0
P13196
Q5JAM2
Q5W5X9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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