ALAS1 and LRRC45

Data Source:
BioGRID (two hybrid)

		ALAS1	LRRC45
Description		5'-aminolevulinate synthase 1	leucine rich repeat containing 45
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nucleoplasm Centrosome Cytosol Plasma Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process Hemoglobin Biosynthetic Process Erythrocyte Development
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Neuroblastoma (pediatric) ( 32599975) Refractive error ( 32231278)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	10 interacting genes: ALAS1 CCDC89 KXD1 MCC MID2 SSX2 SSX2B SSX7 THAP11 ZDHHC17
Entrez ID		211	201255
HPRD ID		00505	14476
Ensembl ID		ENSG00000023330	ENSG00000169683
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q96CN5
PDB IDs
Enriched GO Terms of Interacting Partners?
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