ALAS1 and COBL

Data Source:
BioGRID (two hybrid)

		ALAS1	COBL
Description		5'-aminolevulinate synthase 1	cordon-bleu WH2 repeat protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Ruffle Actin Filament Plasma Membrane Cell Cortex Membrane Axon Dendrite Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Terminal Web
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Actin Monomer Binding Protein Binding
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Embryonic Axis Specification Somite Specification Neural Tube Closure Liver Development Actin Filament Polymerization Notochord Development Floor Plate Development Digestive Tract Development Collateral Sprouting In Absence Of Injury Actin Filament Network Formation Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Fractures ( 30158200) Late-onset Alzheimer's disease ( 27770636) Macular thickness ( 30535121) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Type 1 diabetes ( 19430480) Urate levels in obese individuals ( 25811787) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920) Wegener's granulomatosis ( 23740775)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	2 interacting genes: ALAS1 PACSIN2
Entrez ID		211	23242
HPRD ID		00505	10843
Ensembl ID		ENSG00000023330	ENSG00000106078
Uniprot IDs		B4DVA0 P13196 Q5JAM2	O75128
PDB IDs			4PL8
Enriched GO Terms of Interacting Partners?
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