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PIK3CB and HPS6
Data Source:
BioGRID
(two hybrid)
PIK3CB
HPS6
Description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Membrane
Midbody
Intracellular Membrane-bounded Organelle
Lysosomal Membrane
Endoplasmic Reticulum
Membrane
BLOC-2 Complex
Early Endosome Membrane
Molecular Function
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Phosphatidylinositol 3-kinase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Phosphatidylinositol Kinase Activity
Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
Protein Binding
GTP-dependent Protein Binding
Small GTPase Binding
Biological Process
Activation Of MAPK Activity
Regulation Of Cell-matrix Adhesion
Response To Ischemia
Sphingosine-1-phosphate Receptor Signaling Pathway
Phosphatidylinositol Biosynthetic Process
Endocytosis
Autophagy
Chemotaxis
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Axon Guidance
Positive Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Phosphorylation
Cell Migration
Cytokine-mediated Signaling Pathway
Platelet Activation
Positive Regulation Of Neutrophil Apoptotic Process
Positive Regulation Of Rac Protein Signal Transduction
Phosphatidylinositol-3-phosphate Biosynthetic Process
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of MAP Kinase Activity
Phosphatidylinositol Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Platelet Aggregation
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Sprouting Angiogenesis
Regulation Of Clathrin-dependent Endocytosis
Organelle Organization
Blood Coagulation
Melanocyte Differentiation
Lysosome Localization
Protein Localization To Membrane
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Drugs
Caffeine
XL765
Diseases
Hermansky-Pudlak syndrome (HPS)
GWAS
Male-pattern baldness (
28196072
)
Mean platelet volume (
32888494
)
Household income (MTAG) (
31844048
)
Intelligence (MTAG) (
29326435
)
Interacting Genes
12 interacting genes:
AGTR2
ALAS1
DVL3
HCK
HPS6
LRRK2
MME
PIK3R1
PRKCD
PRKCE
RAB5B
YWHAQ
10 interacting genes:
CREB1
EP300
HPS5
MARK4
MNAT1
OSGEP
PIK3CB
PUM3
SUMO2
TTC19
Entrez ID
5291
79803
HPRD ID
04234
08471
Ensembl ID
ENSG00000051382
ENSG00000166189
Uniprot IDs
B4DER4
B4DZI3
P42338
Q86YV9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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