ALAS1 and ZFYVE26

Data Source:
BioGRID (two hybrid)

		ALAS1	ZFYVE26
Description		5'-aminolevulinate synthase 1	zinc finger FYVE-type containing 26
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Lysosomal Membrane Centrosome Midbody
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Mitotic Cytokinesis Double-strand Break Repair Via Homologous Recombination Regulation Of Cytokinesis
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 31959851) Asthma (childhood onset) ( 31036433)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	35 interacting genes: ALAS1 ASB15 CBY2 CCDC125 CCDC136 CEP44 GOLGA2 GPRASP2 HMBOX1 HNRNPC HOOK2 KRT15 KRT27 KRT34 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MAGED1 MDFI PLEKHF2 PNMA1 PNMA5 PPP1R16A PRDM6 SPAG5 SSX2IP TADA2A TCEANC TDO2 TFIP11 TRAF1 TTC23 USHBP1 USP20
Entrez ID		211	23503
HPRD ID		00505	15734
Ensembl ID		ENSG00000023330	ENSG00000072121
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q68DK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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