ALAS1 and MTSS2

Data Source:
BioGRID (two hybrid)

		ALAS1	MTSS2
Description		5'-aminolevulinate synthase 1	MTSS I-BAR domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Lamellipodium Cortical Actin Cytoskeleton Ruffle Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Actin Monomer Binding GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Small GTPase Binding
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Plasma Membrane Organization Cellular Response To Platelet-derived Growth Factor Stimulus Activation Of GTPase Activity Ruffle Assembly Lamellipodium Organization
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	2 interacting genes: ALAS1 SCAF1
Entrez ID		211	92154
HPRD ID		00505	14289
Ensembl ID		ENSG00000023330	ENSG00000132613
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q765P7
PDB IDs
Enriched GO Terms of Interacting Partners?
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