PLAUR and FAP

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo, in vitro)

		PLAUR	FAP
Description		plasminogen activator, urokinase receptor	fibroblast activation protein alpha
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Specific Granule Membrane	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Lamellipodium Lamellipodium Membrane Ruffle Membrane Apical Part Of Cell Basal Part Of Cell Peptidase Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Angiogenesis Proteolysis Cell Adhesion Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Endothelial Cell Migration Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Fibrinolysis Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Arrest Melanocyte Proliferation Positive Regulation Of Execution Phase Of Apoptosis Melanocyte Apoptotic Process Negative Regulation Of Extracellular Matrix Organization
Pathways		Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Alteplase Urokinase Tenecteplase WX-UK1 Lanoteplase	Sibrotuzumab
Diseases
GWAS		Basophil count ( 32888494) Blood protein levels ( 29875488) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Inflammatory skin disease ( 25574825) Medication use (thyroid preparations) ( 31015401) Regular attendance at a pub or social club ( 29970889) Systemic lupus erythematosus ( 28714469)
Interacting Genes		20 interacting genes: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN	2 interacting genes: DPP4 PLAUR
Entrez ID		5329	2191
HPRD ID		01421	02674
Ensembl ID		ENSG00000011422	ENSG00000078098
Uniprot IDs		M0R1I2 Q03405	B4DLR2 Q12884
PDB IDs		1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI	1Z68
Enriched GO Terms of Interacting Partners?
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