LARP7 and JMJD6

Data Source:
BioGRID (two hybrid)

		LARP7	JMJD6
Description		La ribonucleoprotein 7, transcriptional regulator	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol 7SK SnRNP Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding 7SK SnRNA Binding	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Box C/D RNA 3'-end Processing MRNA Processing Spermatogenesis RNA Splicing Cell Differentiation Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II U6 2'-O-snRNA Methylation	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation
Pathways			HDMs demethylate histones
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Meat-related diet ( 32066663) Subcortical volume (MOSTest) ( 32665545)	Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		76 interacting genes: APP JMJD6 LRRK2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRPF40A RN7SK	27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		51574	23210
HPRD ID		17095	05371
Ensembl ID		ENSG00000174720	ENSG00000070495
Uniprot IDs		Q4G0J3	Q6NYC1
PDB IDs		4WKR 5KNW 6D12	3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?
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