Description |
platelet derived growth factor receptor like |
mitogen-activated protein kinase kinase 1 |
Image |
No pdb structure |
|
Cellular Component |
|
|
Molecular Function |
|
|
Biological Process |
|
|
Pathways |
|
|
Drugs |
|
- K-252a
- 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- Cobimetinib
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- PD-0325901
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
- Selumetinib
|
Diseases |
|
|
GWAS |
- Amyotrophic lateral sclerosis (sporadic) ( 24529757)
- Hippocampal volume in normal cognition ( 29274321)
- Placental abruption ( 29884306)
- Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
- Plasma parathyroid hormone levels ( 30134803)
- Spatial memory ( 31596458)
- Sphingomyelin 24:0 levels ( 31560688)
|
|
Interacting Genes |
24 interacting genes:
ASPH
BAAT
CCDC180
CTSV
FANCC
FBP2
HRAS
MAP2K1
MAPK12
MAPK3
MBP
NANS
PFKM
PPP2CB
PPP3R2
RANGAP1
SFRP4
SMAD1
SPARCL1
TBC1D2
TGFB1
TMEM129
XPA
ZNF510
|
67 interacting genes:
APC
ARAF
AURKA
BANP
BAX
BIRC6
BMPR1A
BRAF
BUB1
CASP9
CDH1
CDK5
CDKN2A
CPNE1
CPNE4
CTNNA1
EGFR
ELK1
EP300
ERBB2
FBXW7
GRB10
HNRNPD
HRAS
KAT7
KSR1
KSR2
LAMTOR3
MAP3K4
MAP3K8
MAPK1
MAPK14
MAPK3
MAPK8
MAPK8IP3
MBP
MLH3
MSH6
MYC
ODC1
PAK1
PARVA
PDGFRL
PEBP1
PEBP4
PIK3CA
PLEKHF2
PLK3
PPARG
PRKCI
PRKCZ
PTPRJ
RAF1
RPS6KA2
RPS6KA4
SMAD2
SRC
STK11
TCP11
TGFBR2
TLR2
TRAF3
TRAF6
TRIB1
UBE2I
UBE2L3
WNK1
|
Entrez ID |
5157 |
5604 |
HPRD ID |
05206 |
01469 |
Ensembl ID |
ENSG00000104213
|
ENSG00000169032
|
Uniprot IDs |
Q15198
|
A4QPA9
B4DFY5
H3BRW9
Q02750
|
PDB IDs |
|
1S9J
2P55
3DV3
3DY7
3E8N
3EQB
3EQC
3EQD
3EQF
3EQG
3EQH
3EQI
3MBL
3ORN
3OS3
3PP1
3SLS
3V01
3V04
3VVH
3W8Q
3WIG
3ZLS
3ZLW
3ZLX
3ZLY
3ZM4
4AN2
4AN3
4AN9
4ANB
4ARK
4LMN
4MNE
4U7Z
4U80
4U81
5BX0
5EYM
5HZE
5YT3
6NYB
6PP9
6Q0J
6Q0T
6U2G
6X2P
6X2S
6X2X
|
Enriched GO Terms of Interacting Partners? |
|
|
Tagcloud ? |
|
|
Tagcloud (Difference) ? |
|
|
Tagcloud (Intersection) ? |
|