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MAP2K1 and BAX
Data Source:
BioGRID
(two hybrid)
MAP2K1
BAX
Description
mitogen-activated protein kinase kinase 1
BCL2 associated X, apoptosis regulator
Image
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Plasma Membrane
Focal Adhesion
Nucleus
Nuclear Envelope
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Permeability Transition Pore Complex
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Pore Complex
Extracellular Exosome
Cell Periphery
Bcl-2 Family Protein Complex
BAX Complex
BAK Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
MAP-kinase Scaffold Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Protein Serine/threonine Kinase Activator Activity
Protein N-terminus Binding
Scaffold Protein Binding
Protein Binding
Lipid Binding
Channel Activity
Hsp70 Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Chaperone Binding
BH3 Domain Binding
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Protein Phosphorylation
Chemotaxis
Cell Cycle Arrest
Signal Transduction
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Cerebellar Cortex Formation
Neuron Differentiation
Keratinocyte Differentiation
Thyroid Gland Development
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Transcription, DNA-templated
Thymus Development
Regulation Of Axon Regeneration
Cell Motility
Positive Regulation Of Axonogenesis
Bergmann Glial Cell Differentiation
Face Development
Trachea Formation
Epithelial Cell Proliferation Involved In Lung Morphogenesis
Placenta Blood Vessel Development
Labyrinthine Layer Development
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Golgi Inheritance
Cellular Senescence
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Regulation Of Early Endosome To Late Endosome Transport
Ovarian Follicle Development
Neuron Migration
T Cell Homeostatic Proliferation
B Cell Homeostasis
B Cell Apoptotic Process
Kidney Development
Release Of Cytochrome C From Mitochondria
Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
B Cell Homeostatic Proliferation
Positive Regulation Of B Cell Apoptotic Process
Transcription Initiation From RNA Polymerase II Promoter
Glycosphingolipid Metabolic Process
Regulation Of Nitrogen Utilization
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Germ Cell Development
Mitochondrial Fusion
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Apoptotic Mitochondrial Changes
Fertilization
Response To Toxic Substance
Response To Salt Stress
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Negative Regulation Of Mitochondrial Membrane Potential
Viral Process
Hypothalamus Development
Cerebral Cortex Development
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Binding
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Release Of Matrix Enzymes From Mitochondria
Negative Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Mammary Gland Epithelial Cell Proliferation
Cellular Response To Unfolded Protein
Cellular Response To UV
Ectopic Germ Cell Programmed Cell Death
Odontogenesis Of Dentin-containing Tooth
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Development Of Secondary Sexual Characteristics
Retinal Cell Programmed Cell Death
Positive Regulation Of Developmental Pigmentation
Negative Regulation Of Fibroblast Proliferation
Spermatid Differentiation
Post-embryonic Camera-type Eye Morphogenesis
Response To Axon Injury
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Regulation Of Mitochondrial Membrane Potential
Sertoli Cell Proliferation
Retina Development In Camera-type Eye
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Vagina Development
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Mitochondrion Morphogenesis
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Blood Vessel Morphogenesis
Apoptotic Process Involved In Embryonic Digit Morphogenesis
Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death
Positive Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of IRE1-mediated Unfolded Protein Response
B Cell Receptor Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
MAPK3 (ERK1) activation
Frs2-mediated activation
Signal transduction by L1
Uptake and function of anthrax toxins
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
Release of apoptotic factors from the mitochondria
Activation, translocation and oligomerization of BAX
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Transcriptional regulation by RUNX2
NTRK3 as a dependence receptor
Drugs
K-252a
5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Cobimetinib
Bosutinib
(5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
PD-0325901
N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
Trametinib
Selumetinib
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Colorectal cancer
GWAS
Prostate cancer (
29892016
)
Testicular germ cell tumor (
28604728
28604732
)
Asthma (
27611488
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (
32888494
)
Interacting Genes
67 interacting genes:
APC
ARAF
AURKA
BANP
BAX
BIRC6
BMPR1A
BRAF
BUB1
CASP9
CDH1
CDK5
CDKN2A
CPNE1
CPNE4
CTNNA1
EGFR
ELK1
EP300
ERBB2
FBXW7
GRB10
HNRNPD
HRAS
KAT7
KSR1
KSR2
LAMTOR3
MAP3K4
MAP3K8
MAPK1
MAPK14
MAPK3
MAPK8
MAPK8IP3
MBP
MLH3
MSH6
MYC
ODC1
PAK1
PARVA
PDGFRL
PEBP1
PEBP4
PIK3CA
PLEKHF2
PLK3
PPARG
PRKCI
PRKCZ
PTPRJ
RAF1
RPS6KA2
RPS6KA4
SMAD2
SRC
STK11
TCP11
TGFBR2
TLR2
TRAF3
TRAF6
TRIB1
UBE2I
UBE2L3
WNK1
30 interacting genes:
ANP32B
BAK1
BBC3
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L12
BCL2L2
BID
ERN1
HSF2BP
KCNA3
LEF1
MAP2K1
MCL1
MOAP1
NOL3
PARK7
PMAIP1
PPP1CA
SFN
SH3GLB1
SLC25A4
TP53
UHRF2
VDAC1
YWHAB
YWHAQ
ZBTB24
Entrez ID
5604
581
HPRD ID
01469
02498
Ensembl ID
ENSG00000169032
ENSG00000087088
Uniprot IDs
A4QPA9
B4DFY5
H3BRW9
Q02750
I6LPK7
Q07812
Q5ZPJ0
Q5ZPJ1
PDB IDs
1S9J
2P55
3DV3
3DY7
3E8N
3EQB
3EQC
3EQD
3EQF
3EQG
3EQH
3EQI
3MBL
3ORN
3OS3
3PP1
3SLS
3V01
3V04
3VVH
3W8Q
3WIG
3ZLS
3ZLW
3ZLX
3ZLY
3ZM4
4AN2
4AN3
4AN9
4ANB
4ARK
4LMN
4MNE
4U7Z
4U80
4U81
5BX0
5EYM
5HZE
5YT3
6NYB
6PP9
6Q0J
6Q0T
6U2G
6X2P
6X2S
6X2X
1F16
2G5B
2K7W
2LR1
3PK1
3PL7
4BD2
4BD6
4BD7
4BD8
4BDU
4S0O
4S0P
4UF2
4ZIE
4ZIF
4ZIG
4ZIH
4ZII
5W5X
5W5Z
5W60
5W61
6EB6
6TRR
6XY6
Enriched GO Terms of Interacting Partners
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