Description |
mitogen-activated protein kinase kinase 1 |
transforming growth factor beta receptor 2 |
Image |
|
|
Cellular Component |
|
|
Molecular Function |
|
|
Biological Process |
|
|
Pathways |
|
|
Drugs |
- K-252a
- 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- Cobimetinib
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- PD-0325901
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
- Selumetinib
|
|
Diseases |
|
|
GWAS |
|
- Breast cancer ( 29059683 23535729)
- Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168)
- Cognitive decline rate in late mild cognitive impairment ( 26252872)
- Estimated glomerular filtration rate ( 31152163)
- Heel bone mineral density ( 30598549)
- Metabolite levels ( 23823483)
- Migraine ( 22683712 27322543)
- Migraine - clinic-based ( 23793025)
- Night sleep phenotypes ( 27126917)
- Postprandial triglyceride response ( 32603185)
- Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820)
- Systolic blood pressure ( 30224653)
- Tonometry ( 17903302)
|
Interacting Genes |
67 interacting genes:
APC
ARAF
AURKA
BANP
BAX
BIRC6
BMPR1A
BRAF
BUB1
CASP9
CDH1
CDK5
CDKN2A
CPNE1
CPNE4
CTNNA1
EGFR
ELK1
EP300
ERBB2
FBXW7
GRB10
HNRNPD
HRAS
KAT7
KSR1
KSR2
LAMTOR3
MAP3K4
MAP3K8
MAPK1
MAPK14
MAPK3
MAPK8
MAPK8IP3
MBP
MLH3
MSH6
MYC
ODC1
PAK1
PARVA
PDGFRL
PEBP1
PEBP4
PIK3CA
PLEKHF2
PLK3
PPARG
PRKCI
PRKCZ
PTPRJ
RAF1
RPS6KA2
RPS6KA4
SMAD2
SRC
STK11
TCP11
TGFBR2
TLR2
TRAF3
TRAF6
TRIB1
UBE2I
UBE2L3
WNK1
|
50 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CCNB1
CCNB2
CD44
CDK1
CLU
CTNNB1
DAB2
DAXX
DYNLT4
EIF3I
ENG
FANCC
GOPC
KCNK18
MAP2K1
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PPP2CB
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TDGF1
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TRMO
TSSK1B
ZFYVE9
ZNF510
|
Entrez ID |
5604 |
7048 |
HPRD ID |
01469 |
01823 |
Ensembl ID |
ENSG00000169032
|
ENSG00000163513
|
Uniprot IDs |
A4QPA9
B4DFY5
H3BRW9
Q02750
|
A3QNQ0
D2JYI1
P37173
|
PDB IDs |
1S9J
2P55
3DV3
3DY7
3E8N
3EQB
3EQC
3EQD
3EQF
3EQG
3EQH
3EQI
3MBL
3ORN
3OS3
3PP1
3SLS
3V01
3V04
3VVH
3W8Q
3WIG
3ZLS
3ZLW
3ZLX
3ZLY
3ZM4
4AN2
4AN3
4AN9
4ANB
4ARK
4LMN
4MNE
4U7Z
4U80
4U81
5BX0
5EYM
5HZE
5YT3
6NYB
6PP9
6Q0J
6Q0T
6U2G
6X2P
6X2S
6X2X
|
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
|
Enriched GO Terms of Interacting Partners? |
|
|
Tagcloud ? |
|
|
Tagcloud (Difference) ? |
|
|
Tagcloud (Intersection) ? |
|