Description |
mitogen-activated protein kinase kinase 1 |
cyclin dependent kinase inhibitor 2A |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- K-252a
- 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- Cobimetinib
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- PD-0325901
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
- Selumetinib
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Diseases |
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GWAS |
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Interacting Genes |
67 interacting genes:
APC
ARAF
AURKA
BANP
BAX
BIRC6
BMPR1A
BRAF
BUB1
CASP9
CDH1
CDK5
CDKN2A
CPNE1
CPNE4
CTNNA1
EGFR
ELK1
EP300
ERBB2
FBXW7
GRB10
HNRNPD
HRAS
KAT7
KSR1
KSR2
LAMTOR3
MAP3K4
MAP3K8
MAPK1
MAPK14
MAPK3
MAPK8
MAPK8IP3
MBP
MLH3
MSH6
MYC
ODC1
PAK1
PARVA
PDGFRL
PEBP1
PEBP4
PIK3CA
PLEKHF2
PLK3
PPARG
PRKCI
PRKCZ
PTPRJ
RAF1
RPS6KA2
RPS6KA4
SMAD2
SRC
STK11
TCP11
TGFBR2
TLR2
TRAF3
TRAF6
TRIB1
UBE2I
UBE2L3
WNK1
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168 interacting genes:
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ACLY
ACTB
ACTG1
ACTN4
AHNAK
AKT1
ALDOB
ANAPC15
ANGPTL4
ANKRA2
ANKRD12
AOPEP
ARFIP2
ARNT
ASPRV1
AZIN1
BAAT
BCL2L1
BECN1
CARF
CASC3
CCDC180
CCDC183
CCND2
CCNDBP1
CCNE1
CCNG1
CD44
CDC14B
CDC42
CDC45
CDC5L
CDC6
CDC7
CDK4
CDK6
CDKN2AIP
CDKN2B
CDKN2C
CENPA
CRELD2
CTBP2
CTSV
CYLC2
DEAF1
E2F1
E4F1
EEF2
EFHC2
EGR1
EPHA2
EPHA3
EXOC2
FGFR4
FN1
FRAT2
FZR1
GALNT12
GAPDH
GGA1
GGA3
GLIS1
GLIS2
GMNN
GSPT1
H2BU1
HGF
HIF1A
HLA-DOB
HNRNPA2B1
HNRNPC
HNRNPU
HRAS
HSP90AA1
HSP90AB1
HSPA4
HSPA8
HUWE1
ISOC2
KAT5
LATS2
MAF1
MAP2K1
MAP2K5
MAP3K5
MAPK10
MAPK14
MAPK3
MAPK8
MCM10
MCM2
MCM5
MCM6
MDM2
MDM4
MMRN1
MTR
MYC
MYL12A
NAT2
NCL
NMI
NOP53
NPM1
NSD3
ORC4
PCNA
PDCD6
PDGFRA
PEX19
PPP1R9B
PRKCA
PSMC3
PTP4A3
RAF1
RASA1
RASSF1
RBM26
RIN2
RPL11
RPS7
RUVBL2
SEC61B
SERTAD1
SFRP4
SIVA1
SIX2
SLC4A1
SMARCA4
SNRPA
SNRPB
SOX3
SOX4
STK11
TBRG1
TDRD7
TEAD2
TERT
TFDP1
TGFB1
TMEFF1
TMOD1
TP53
TP63
TPI1
TRIM28
TRIP12
TSC1
TUBA1A
TUBA1C
TUBB
TUBB4B
UBE2A
UBE4B
UBL7
USP26
VAMP1
VHL
WRN
YY1
ZFP91
ZGRF1
ZNF227
ZNF410
ZNF420
ZNF687
ZUP1
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Entrez ID |
5604 |
1029 |
HPRD ID |
01469 |
02542 |
Ensembl ID |
ENSG00000169032
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ENSG00000147889
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Uniprot IDs |
A4QPA9
B4DFY5
H3BRW9
Q02750
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K7PML8
P42771
Q8N726
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PDB IDs |
1S9J
2P55
3DV3
3DY7
3E8N
3EQB
3EQC
3EQD
3EQF
3EQG
3EQH
3EQI
3MBL
3ORN
3OS3
3PP1
3SLS
3V01
3V04
3VVH
3W8Q
3WIG
3ZLS
3ZLW
3ZLX
3ZLY
3ZM4
4AN2
4AN3
4AN9
4ANB
4ARK
4LMN
4MNE
4U7Z
4U80
4U81
5BX0
5EYM
5HZE
5YT3
6NYB
6PP9
6Q0J
6Q0T
6U2G
6X2P
6X2S
6X2X
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1A5E
1BI7
1DC2
2A5E
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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