Description |
mitogen-activated protein kinase kinase 1 |
myelin basic protein |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- K-252a
- 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- Cobimetinib
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- PD-0325901
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
- Selumetinib
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Diseases |
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GWAS |
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- Age-related macular degeneration (geographic atrophy) ( 22705344)
- Blood osmolality (transformed sodium) ( 28360221)
- Depression in smokers ( 30219690)
- Erythrocyte cadmium concentration in never smokers ( 27005419)
- Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
- Verbal declarative memory ( 25648963)
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Interacting Genes |
67 interacting genes:
APC
ARAF
AURKA
BANP
BAX
BIRC6
BMPR1A
BRAF
BUB1
CASP9
CDH1
CDK5
CDKN2A
CPNE1
CPNE4
CTNNA1
EGFR
ELK1
EP300
ERBB2
FBXW7
GRB10
HNRNPD
HRAS
KAT7
KSR1
KSR2
LAMTOR3
MAP3K4
MAP3K8
MAPK1
MAPK14
MAPK3
MAPK8
MAPK8IP3
MBP
MLH3
MSH6
MYC
ODC1
PAK1
PARVA
PDGFRL
PEBP1
PEBP4
PIK3CA
PLEKHF2
PLK3
PPARG
PRKCI
PRKCZ
PTPRJ
RAF1
RPS6KA2
RPS6KA4
SMAD2
SRC
STK11
TCP11
TGFBR2
TLR2
TRAF3
TRAF6
TRIB1
UBE2I
UBE2L3
WNK1
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81 interacting genes:
ABL1
ADRB2
APTX
ATN1
ATXN1
AURKA
BMP2K
CCR1
CDK1
CDK12
CDK5
CDK7
CDK8
CDK9
CLK1
CTDSP1
CTDSPL
DYRK1B
HIPK2
HLA-DRA
IKBKE
ILK
IRAK1
IRAK4
LIMK1
LIMK2
LRRK2
MAG
MAP2K1
MAP3K1
MAP3K3
MAP3K5
MAPK1
MAPK11
MAPK12
MAPK13
MAPK14
MAPK15
MAPK3
MAPK8
MAPKAPK5
MELK
MICU2
MKNK1
MMP7
NEK9
PAK1
PDGFRL
PKN1
PLEKHF2
PLP1
PPP2R5C
PRKACA
PRKCA
PRKCB
PRKCD
PRKCI
PRKCZ
PRKDC
PRMT1
PRMT5
PTAFR
PTPRA
RAF1
RAN
RPS6KA5
RTN4
SQSTM1
SRPK1
STK16
STK26
STK3
STK39
STK4
TBK1
TLK1
TLK2
TRAF6
TRPM7
TSSK6
ULK1
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Entrez ID |
5604 |
4155 |
HPRD ID |
01469 |
01158 |
Ensembl ID |
ENSG00000169032
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ENSG00000197971
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Uniprot IDs |
A4QPA9
B4DFY5
H3BRW9
Q02750
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A0A024R384
P02686
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PDB IDs |
1S9J
2P55
3DV3
3DY7
3E8N
3EQB
3EQC
3EQD
3EQF
3EQG
3EQH
3EQI
3MBL
3ORN
3OS3
3PP1
3SLS
3V01
3V04
3VVH
3W8Q
3WIG
3ZLS
3ZLW
3ZLX
3ZLY
3ZM4
4AN2
4AN3
4AN9
4ANB
4ARK
4LMN
4MNE
4U7Z
4U80
4U81
5BX0
5EYM
5HZE
5YT3
6NYB
6PP9
6Q0J
6Q0T
6U2G
6X2P
6X2S
6X2X
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1BX2
1FV1
1HQR
1K2D
1QCL
1YMM
1ZGL
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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