PDGFRL and SFRP4

Data Source:
BioGRID (two hybrid)

		PDGFRL	SFRP4
Description		platelet derived growth factor receptor like	secreted frizzled related protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Extracellular Region	Extracellular Space Nucleus Cytoplasm Cell Surface
	Molecular Function	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity	Protein Binding Wnt-protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Biological_process Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport
Pathways
Drugs			Cyclothiazide Perindopril
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hippocampal volume in normal cognition ( 29274321) Placental abruption ( 29884306) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma parathyroid hormone levels ( 30134803) Spatial memory ( 31596458) Sphingomyelin 24:0 levels ( 31560688)	Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510	21 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4
Entrez ID		5157	6424
HPRD ID		05206	07357
Ensembl ID		ENSG00000104213	ENSG00000106483
Uniprot IDs		Q15198	Q6FHJ7
PDB IDs
Enriched GO Terms of Interacting Partners?
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