WDR77 and RBM5

Data Source:
BioGRID (two hybrid)

		WDR77	RBM5
Description		WD repeat domain 77	RNA binding motif protein 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Pole Plasm	Nucleus Nucleoplasm Spliceosomal Complex
	Molecular Function	Protein Binding Methyl-CpG Binding Nuclear Receptor Coactivator Activity	DNA Binding RNA Binding MRNA Binding Protein Binding Metal Ion Binding
	Biological Process	Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Pole Plasm Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription, DNA-templated Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process
Pathways		snRNP Assembly RMTs methylate histone arginines	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Age at first birth ( 27798627) Blood protein levels ( 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Dentures ( 31235808) Extremely high intelligence ( 29520040) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Morning person ( 30696823) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		44 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 RIOK1 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZMYND19 ZNF207	28 interacting genes: BCL2L1 CASK DCX DDX17 GAPDH ILF3 KIF19 KIF9 LIG4 LRIF1 LSM8 MED1 MEOX1 MEOX2 MIRLET7D MIRLET7E MIRLET7G MIRLET7I MLYCD NDEL1 PARD3B PCM1 PKP2 POMP RBM14 WBP11 WDR77 ZDHHC17
Entrez ID		79084	10181
HPRD ID		14387	06052
Ensembl ID		ENSG00000116455	ENSG00000003756
Uniprot IDs		A0A024R0H7 Q9BQA1	A0A024R2U6 P52756
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UXX 6UXY 6V0N 6V0O	2LK0 2LK1 2LKZ 5MF9 5MFY
Enriched GO Terms of Interacting Partners?
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