POLR1E and UBTF

Data Source:
HPRD (in vivo, in vitro)

		POLR1E	UBTF
Description		RNA polymerase I subunit E	upstream binding transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus RNA Polymerase I Complex	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Nucleolar Large RRNA Transcription By RNA Polymerase I Positive Regulation Of Gene Expression, Epigenetic	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		8 interacting genes: NFKBIB POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF	33 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 EP300 IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2
Entrez ID		64425	7343
HPRD ID		15096	02814
Ensembl ID		ENSG00000137054	ENSG00000108312
Uniprot IDs		B4E005 Q9GZS1	P17480
PDB IDs			1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?
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