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PDE9A and TRIM32
Data Source:
HPRD
(two hybrid)
PDE9A
TRIM32
Description
phosphodiesterase 9A
tripartite motif containing 32
Image
GO Annotations
Cellular Component
Nucleoplasm
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Ruffle Membrane
Sarcolemma
Perikaryon
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Cytosol
Striated Muscle Myosin Thick Filament
Molecular Function
3',5'-cyclic-nucleotide Phosphodiesterase Activity
Protein Binding
Metal Ion Binding
3',5'-cyclic-GMP Phosphodiesterase Activity
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Myosin Binding
Tat Protein Binding
Translation Initiation Factor Binding
Identical Protein Binding
Ubiquitin Binding
Protein Self-association
Ubiquitin Protein Ligase Activity
Biological Process
Signal Transduction
Positive Regulation Of Cardiac Muscle Hypertrophy
CGMP-mediated Signaling
CGMP Metabolic Process
CGMP Catabolic Process
Protein Polyubiquitination
Tissue Homeostasis
Ubiquitin-dependent Protein Catabolic Process
Actin Ubiquitination
Response To UV
Protein Ubiquitination
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Response To Tumor Necrosis Factor
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Fat Cell Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Cycle
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription, DNA-templated
Muscle Cell Cellular Homeostasis
Negative Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Striated Muscle Cell Differentiation
Axon Development
Protein K48-linked Ubiquitination
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production
Positive Regulation Of Cell Motility
Pathways
cGMP effects
Regulation of innate immune responses to cytosolic DNA
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Caffeine
gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine
3-isobutyl-1-methyl-7H-xanthine
Trapidil
Diseases
Bardet-Biedl syndrome (BBS)
GWAS
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Perceived unattractiveness to mosquitoes (
28199695
)
Estimated glomerular filtration rate (
31015462
)
Interacting Genes
36 interacting genes:
BAG3
C9orf106
CDC37
CLK1
CRY2
CYSRT1
GORASP2
IQCB1
KANK2
KRT34
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP4-2
KRTAP5-9
KRTAP9-2
LAGE3
LMO2
NAA38
NFIL3
NOTCH2NLA
PHYHIPL
PRPF18
SDCBP
SULT1E1
TFAP4
TRIM32
TRPV6
UBD
UTP23
WDR5
63 interacting genes:
ABI2
AKTIP
ATXN1
CLIP4
DERL1
ERGIC3
FADS6
GABARAP
GABARAPL1
GABARAPL2
GEM
GLIS2
GPR137B
HSPA4
ICMT
IQCB1
IRAK1
KCTD9
LCN2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MID2
MOB1A
MYCN
NDRG2
NTAQ1
PDE9A
PELI2
PIAS3
PIAS4
PTCD2
PTPN11
RAB29
RABAC1
RNF208
RNF41
SCGB1A1
SDCBP
STING1
SYT6
TCEANC
TOP1
TRIM23
TRIM27
TRIM5
TRIM72
TTC23
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBE2V1
UBQLN1
UBQLN2
UBQLN4
VPS11
XIAP
Entrez ID
5152
22954
HPRD ID
09115
03797
Ensembl ID
ENSG00000160191
ENSG00000119401
Uniprot IDs
A0A0S2Z475
A0A0S2Z4A3
A0A0S2Z4T6
O76083
A0A024R843
Q13049
PDB IDs
2HD1
2YY2
3DY8
3DYL
3DYN
3DYQ
3DYS
3JSI
3JSW
3K3E
3K3H
3N3Z
3QI3
3QI4
4E90
4G2J
4G2L
4GH6
4Y86
4Y87
4Y8C
6A3N
2CT2
5FEY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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