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TRIM32 and TRIM5
Data Source:
BioGRID
(two hybrid)
TRIM32
TRIM5
Description
tripartite motif containing 32
tripartite motif containing 5
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Striated Muscle Myosin Thick Filament
P-body
Nucleoplasm
Cytoplasm
Cytosol
Omegasome
Molecular Function
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Myosin Binding
Tat Protein Binding
Translation Initiation Factor Binding
Identical Protein Binding
Ubiquitin Binding
Protein Self-association
Ubiquitin Protein Ligase Activity
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Pattern Recognition Receptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Biological Process
Protein Polyubiquitination
Tissue Homeostasis
Ubiquitin-dependent Protein Catabolic Process
Actin Ubiquitination
Response To UV
Protein Ubiquitination
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Response To Tumor Necrosis Factor
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Fat Cell Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Cycle
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription, DNA-templated
Muscle Cell Cellular Homeostasis
Negative Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Striated Muscle Cell Differentiation
Axon Development
Protein K48-linked Ubiquitination
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production
Positive Regulation Of Cell Motility
Protein Polyubiquitination
Activation Of Innate Immune Response
Autophagy
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Viral Process
Protein Ubiquitination
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Protein Localization
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Negative Regulation Of Viral Release From Host Cell
Pathways
Regulation of innate immune responses to cytosolic DNA
Antigen processing: Ubiquitination & Proteasome degradation
Interferon gamma signaling
Drugs
Diseases
Bardet-Biedl syndrome (BBS)
GWAS
Estimated glomerular filtration rate (
31015462
)
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
Coronary artery disease (
29212778
33020668
)
DNA methylation (variation) (
23725790
)
HDL cholesterol levels (
32203549
)
LDL cholesterol levels (
32203549
)
Low density lipoprotein cholesterol levels (
32154731
)
Malaria (
31844061
)
Mean platelet volume (
32888494
27863252
)
Midgestational circulating levels of PBDEs (fetal genetic effect) (
28235828
)
Platelet count (
29403010
32888494
)
Serum alkaline phosphatase levels (
29403010
)
Severe COVID-19 infection with respiratory failure (analysis I) (
32558485
)
Interacting Genes
63 interacting genes:
ABI2
AKTIP
ATXN1
CLIP4
DERL1
ERGIC3
FADS6
GABARAP
GABARAPL1
GABARAPL2
GEM
GLIS2
GPR137B
HSPA4
ICMT
IQCB1
IRAK1
KCTD9
LCN2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MID2
MOB1A
MYCN
NDRG2
NTAQ1
PDE9A
PELI2
PIAS3
PIAS4
PTCD2
PTPN11
RAB29
RABAC1
RNF208
RNF41
SCGB1A1
SDCBP
STING1
SYT6
TCEANC
TOP1
TRIM23
TRIM27
TRIM5
TRIM72
TTC23
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBE2V1
UBQLN1
UBQLN2
UBQLN4
VPS11
XIAP
46 interacting genes:
BTBD1
BTBD2
EHHADH
EWSR1
LGALS8
LZTR1
MKRN3
MNAT1
MPP7
MTURN
NTAQ1
OTUB2
OTUD6A
PCBD1
PIAS1
PRKCG
PSMC2
RUNX1
SGTA
TNFAIP3
TRIM21
TRIM32
TRIM34
TRIM35
TRIM6
TSGA10IP
UBASH3A
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2H
UBE2K
UBE2N
UBE2U
UBE2V1
UBE2V2
UBE2W
USP15
USP2
USP21
USP39
USP5
YES1
Entrez ID
22954
85363
HPRD ID
03797
07004
Ensembl ID
ENSG00000119401
ENSG00000132256
Uniprot IDs
A0A024R843
Q13049
Q9C035
PDB IDs
2CT2
5FEY
2ECV
2YRG
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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