TRIM32 and PDE9A

Data Source:
HPRD (two hybrid)

		TRIM32	PDE9A
Description		tripartite motif containing 32	phosphodiesterase 9A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament	Nucleoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Ruffle Membrane Sarcolemma Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Actin Ubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Striated Muscle Cell Differentiation Axon Development Protein K48-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cell Motility	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP-mediated Signaling CGMP Metabolic Process CGMP Catabolic Process
Pathways		Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	cGMP effects
Drugs			Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Estimated glomerular filtration rate ( 31015462)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Perceived unattractiveness to mosquitoes ( 28199695)
Interacting Genes		63 interacting genes: ABI2 AKTIP ATXN1 CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP STING1 SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN2 UBQLN4 VPS11 XIAP	36 interacting genes: BAG3 C9orf106 CDC37 CLK1 CRY2 CYSRT1 GORASP2 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5
Entrez ID		22954	5152
HPRD ID		03797	09115
Ensembl ID		ENSG00000119401	ENSG00000160191
Uniprot IDs		A0A024R843 Q13049	A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083
PDB IDs		2CT2 5FEY	2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N
Enriched GO Terms of Interacting Partners?
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