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PDE9A and KRT34
Data Source:
BioGRID
(two hybrid)
PDE9A
KRT34
Description
phosphodiesterase 9A
keratin 34
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Ruffle Membrane
Sarcolemma
Perikaryon
Perinuclear Region Of Cytoplasm
Extracellular Space
Cytosol
Intermediate Filament
Molecular Function
3',5'-cyclic-nucleotide Phosphodiesterase Activity
Protein Binding
Metal Ion Binding
3',5'-cyclic-GMP Phosphodiesterase Activity
Structural Molecule Activity
Protein Binding
Biological Process
Signal Transduction
Positive Regulation Of Cardiac Muscle Hypertrophy
CGMP-mediated Signaling
CGMP Metabolic Process
CGMP Catabolic Process
Epidermis Development
Keratinization
Cornification
Pathways
cGMP effects
Keratinization
Formation of the cornified envelope
Drugs
Caffeine
gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine
3-isobutyl-1-methyl-7H-xanthine
Trapidil
Diseases
GWAS
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Perceived unattractiveness to mosquitoes (
28199695
)
Interacting Genes
36 interacting genes:
BAG3
C9orf106
CDC37
CLK1
CRY2
CYSRT1
GORASP2
IQCB1
KANK2
KRT34
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP4-2
KRTAP5-9
KRTAP9-2
LAGE3
LMO2
NAA38
NFIL3
NOTCH2NLA
PHYHIPL
PRPF18
SDCBP
SULT1E1
TFAP4
TRIM32
TRPV6
UBD
UTP23
WDR5
253 interacting genes:
A1CF
ABHD15
ABI2
ADRA2C
AGXT
AIMP2
ALDH3B1
AMOT
ANKRD11
ANKS1A
ARMC7
ASMTL
ATG9A
ATPAF2
BATF2
BCAS2
BEX1
BEX2
BEX3
BHLHE23
BOLA3
BRME1
C11orf87
C17orf50
C1orf216
C5orf49
CBX8
CCDC120
CCDC13
CCDC146
CCDC196
CCDC198
CCDC24
CCDC28A-AS1
CCHCR1
CCNC
CDC20B
CDK18
CERK
CFAP206
CFAP53
CHRD
CHRNG
CLCNKA
CLDN19
CLEC18A
CTRC
CWC25
CYSRT1
CYTH4
DCTN3
DDIT4L
DDX6
DHRS1
DMRT3
DOCK2
EFCAB3
EIF4G1
EPDR1
EXOC8
EXOSC5
FAM110A
FAM214B
FAM50B
FAM71C
FAM83A
FAM90A1
FARS2
FBXW5
FNDC11
FOXD4L1
FRS3
GADD45GIP1
GAST
GATAD2A
GEM
GLYCTK
GNE
GNG10
GNG13
GPS2
GRN
GSC2
GSTP1
HAPLN2
HBA1
HBA2
HCK
HDAC4
HGS
HOXA1
HOXB5
HOXB9
HOXC8
HSPA12B
HSPD1
HYAL2
ICAM4
INIP
INO80B
ISCU
ITGB5
ITPKB
JOSD1
KANK2
KCTD9
KDELR1
KIDINS220
KLC4
KLHL38
KLK8
KRT1
KRT20
KRT3
KRT6A
KRT6C
KRT71
KRT74
KRT75
KRT78
KRT79
KRT8
KRT80
KRT81
KRT82
KRT83
KRT85
KRT86
KRTAP12-2
KRTAP13-1
KRTAP19-5
KRTAP19-7
KRTAP26-1
LMO2
LMO4
LRRC29
LRRC41
LYSMD1
LYVE1
MAB21L2
MAD2L2
MAP3K7CL
MAPKBP1
MATR3
MBD3L2
METTL17
MIDN
MIIP
MKRN3
MNS1
MOS
MSRB3
MYO15B
MYOZ1
MYOZ3
NAB2
NAXD
NEK6
NFKBID
NMU
NOTO
NPBWR2
NUP42
P2RX7
PDE9A
PDGFRB
PGLYRP3
PIN1
PITX1
PITX2
PKN1
PLLP
POP5
PPP1R18
PPP1R27
PPP3R2
PRPF18
PRPF31
PRR19
PRR35
PSMA1
PSMB1
PTPMT1
R3HDM2
RAB33A
RAB3IL1
RASD1
RFC5
RIN1
RIPPLY1
RTP5
SAMD11
SCNM1
SEC14L4
SEMA4C
SHC3
SIRPA
SLC15A2
SLC22A5
SLC23A1
SLC25A42
SMARCD1
SMARCE1
SMCP
SMG9
SNRPB
SPAG8
SPATA46
SPRY3
STMN3
SUOX
TACO1
TAPBPL
TBC1D22B
TCHP
TEKT3
TEKT4
TENT5B
TEPSIN
TFAP2D
THAP7
TLE5
TLX3
TMEM174
TMIE
TMSB4X
TRARG1
TRIM42
TRIM73
TRIML2
TSG101
TTC23
TTC9C
TXLNA
TXLNB
USP2
UTP14C
UTP23
VENTX
WDR25
WWOX
ZDHHC1
ZFHX3
ZFYVE26
ZIC1
ZNF124
ZNF148
ZNF319
ZNF414
ZNF446
ZNF580
ZNF581
ZNF79
Entrez ID
5152
3885
HPRD ID
09115
04137
Ensembl ID
ENSG00000160191
ENSG00000131737
Uniprot IDs
A0A0S2Z475
A0A0S2Z4A3
A0A0S2Z4T6
O76083
O76011
PDB IDs
2HD1
2YY2
3DY8
3DYL
3DYN
3DYQ
3DYS
3JSI
3JSW
3K3E
3K3H
3N3Z
3QI3
3QI4
4E90
4G2J
4G2L
4GH6
4Y86
4Y87
4Y8C
6A3N
Enriched GO Terms of Interacting Partners
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