PCYT1A and RNF8

Data Source:
BioGRID (two hybrid)

		PCYT1A	RNF8
Description		phosphate cytidylyltransferase 1, choline, alpha	ring finger protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Glycogen Granule	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	Choline-phosphate Cytidylyltransferase Activity Protein Binding Phosphatidylcholine Binding Identical Protein Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Phosphatidylcholine Biosynthetic Process CDP-choline Pathway	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Viral Process Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		Synthesis of PC	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs		Choline Choline salicylate
Diseases
GWAS		Mean platelet volume ( 32888494)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		16 interacting genes: ACTB AGTRAP CASP6 CASP8 FKBP7 GYS1 MAGEA3 MOB1A MOB3C PCYT1B RNF8 SCAMP1 SDCBP SNAPIN TNFRSF10D VKORC1L1	76 interacting genes: AMOTL2 BLM C2CD6 CALCOCO1 CCDC14 CCDC50 CCDC85B CEP44 CEP85 CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A KIF24 KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 PCNA PCYT1A PGRMC2 PICK1 PNMA2 POLD4 PSMB1 RBFOX2 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		5130	9025
HPRD ID		00438	11521
Ensembl ID		ENSG00000161217	ENSG00000112130
Uniprot IDs		B4E322 P49585	O76064
PDB IDs			2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?
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