TRAF4 and NOS1AP

Data Source:
BioGRID (two hybrid)

		TRAF4	NOS1AP
Description		TNF receptor associated factor 4	nitric oxide synthase 1 adaptor protein
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Perinuclear Region Of Cytoplasm Plasma Membrane Signaling Receptor Complex	Nucleus Mitochondrion Cytosol Caveola Z Disc T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Perinuclear Region Of Cytoplasm Glutamatergic Synapse Inward Rectifier Potassium Channel Complex L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding WW Domain Binding	Protein Binding Nitric-oxide Synthase Binding
	Biological Process	Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange By Respiratory System Respiratory Tube Development Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein K63-linked Ubiquitination	Regulation Of Heart Rate By Chemical Signal Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Positive Regulation Of Peptidyl-cysteine S-nitrosylation
Pathways
Drugs
Diseases
GWAS			Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Body mass index (change over time) ( 25133637) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062061 20062063 25055868) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Long QT syndrome ( 32429735) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) QT interval ( 23166209 30679814 20031603 29213071 16648850 24952745 22726844 19305408 19305409 19587794 29874175) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Word reading ( 23738518)
Interacting Genes		131 interacting genes: ABI3 ALKBH4 BACH2 BAHD1 BANP BCKDK BCL6B BEGAIN BEX3 BYSL C19orf54 CALCOCO2 CBL CBLC CCHCR1 CENPE CEP85 CHUK DISC1 DNM2 DPEP2NB DTX3 EXOC7 EYA2 EZHIP FAM214B FAM90A1 FAT1 FBXL18 FRS3 FTH1 GOLGA2 GOLGA6A GOLGA6L9 GORASP1 GORASP2 GPRASP1 HEY2 HGS HMG20A HOMEZ HOXA1 HOXB5 IRAK1 ISYNA1 KANK2 KANSL1 KDM1A KRT31 KRT36 KRT40 LENG8 LNX1 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NOS1AP NPAS2 NTRK1 NUDT16L1 PCSK5 PDE4DIP PHLDA1 PICK1 PKD1P1 PLAGL2 PLEKHA7 PLSCR1 POLR2J POLR2J3 PSMC3 QARS1 RAD54L2 RBPMS REXO1L6P RNF114 RNF144B RNF4 RPS6KB1 SF3B4 SIGLEC7 SLC9A3R2 SMURF1 SMURF2 SNRPB SORBS2 SPDL1 SUMO1 TARBP2 TAX1BP1 TBC1D7 TBC1D8 TFAP4 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM27 TRIM37 TSGA10IP TYK2 UBE2D1 UBE2I UBL4A UBL4B UBQLN2 USP7 VPS52 WBP11 WWP1 WWP2 ZBTB16 ZBTB26 ZC3H12C ZMYM5 ZNF177 ZNF275 ZNF3 ZNF512B ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF784 ZNF835 ZRANB1	20 interacting genes: AKNAD1 APP CKM CT45A5 FAM133A FYN HSPD1 LRP1 LRP2 LRP8 NHP2 NOS1 PLAGL2 PNP RASD1 RYBP SYN1 SYN2 SYN3 TRAF4
Entrez ID		9618	9722
HPRD ID		03915	12023
Ensembl ID		ENSG00000076604	ENSG00000198929
Uniprot IDs		A0A024QZ19 A0A024QZ59 Q9BUZ4	O75052
PDB IDs		2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?
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