KRTAP1-1 and SLC6A20

Data Source:
BioGRID (two hybrid)

		KRTAP1-1	SLC6A20
Description		keratin associated protein 1-1	solute carrier family 6 member 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding	Proline:sodium Symporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-isoleucine Transmembrane Transporter Activity L-proline Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity
	Biological Process	Biological_process Keratinization	Amino Acid Transport Glycine Transport Proline Transport Amino-acid Betaine Transport Sodium Ion Transmembrane Transport Amino Acid Import Across Plasma Membrane Transport Across Blood-brain Barrier L-isoleucine Import Across Plasma Membrane L-proline Import Across Plasma Membrane Proline Import Across Plasma Membrane
Pathways		Keratinization	Amino acid transport across the plasma membrane Na+/Cl- dependent neurotransmitter transporters Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)
Drugs
Diseases			Iminoglycinuria
GWAS			Acne (severe) ( 24927181) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hirschsprung disease ( 25310821) Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Macular thickness ( 30535121) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary metabolites ( 26352407 21572414)
Interacting Genes		189 interacting genes: ADAM12 ADAMTSL3 ADAMTSL4 AGXT AKR7A3 ALDH3B1 ALPP AQP1 ASPSCR1 ATG9A BCAM C10orf62 C11orf87 C19orf38 CAMK2B CATIP CATSPER1 CD300LG CERK CHIC2 CHRD CHRNG CLDN2 CNNM3 CRY2 CSF1 CST2 CTRC CTSZ CYHR1 CYSLTR2 CYSRT1 DHRS1 DMRT3 DOCK2 EFNA3 EMC7 FAM221A FAM71C FAM76B FAM90A1 FARS2 FEZF1 FKBP1B FOXD4L3 FRS3 FZD10 GLP1R GNE GRN GSTP1 GUCD1 HCK HEY2 HOXA1 HOXB5 HOXB9 HOXC8 HPCAL1 HSBP1 HYAL2 IFITM2 IGSF8 IL16 INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KRT20 KRTAP10-1 KRTAP10-11 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP13-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-12 KRTAP4-5 KRTAP5-11 KRTAP5-4 KRTAP5-6 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 LRFN4 LRRN4 MAGOHB MAPKBP1 MELTF MGAT5B MRGBP MRPL23 MT1B MXD3 MXI1 MYOM1 NECTIN2 NECTIN3 NMU NPDC1 NR1D2 NTM NUBP2 OLIG3 OR14I1 OTX1 P2RX4 P2RY6 PCSK5 PDE9A PGAP6 PHLDA1 PRKAB2 PRKAG1 PRPF31 PSMA1 PVR QPRT R3HDM2 REM2 RNF111 RPS19BP1 RPS28 RPUSD3 RTN4RL1 SCARF1 SCNM1 SDC3 SEMA3B SHFL SLC23A1 SLC43A2 SLC6A20 SLC7A11 SLIT1 SMARCE1 SMCP SMOC1 SNAI1 SNX18 SPACA9 SPRY1 STK16 TCEANC TFAP2D TGFB1 TNP2 TSFM VASN VGLL3 VSTM4 WNT11 ZBTB48 ZBTB9 ZDHHC1 ZNF124 ZNF330 ZNF408 ZNF439 ZNF440 ZNF446 ZNF491 ZNF497 ZNF524 ZNF581 ZNF587 ZNF648 ZNF669 ZNF696 ZNF786 ZNF837	11 interacting genes: ADAMTSL4 CYSRT1 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 NBPF19 NOTCH2NLA
Entrez ID		81851	54716
HPRD ID		12304	16128
Ensembl ID		ENSG00000188581	ENSG00000163817
Uniprot IDs		Q07627	Q9NP91
PDB IDs
Enriched GO Terms of Interacting Partners?
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