HP1BP3 and FBXO25

Data Source:
BioGRID (enzymatic study)

		HP1BP3	FBXO25
Description		heterochromatin protein 1 binding protein 3	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome Nuclear Speck	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Protein Binding Nucleosome Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Nucleosome Assembly Regulation Of Transcription, DNA-templated Regulation Of Cell Population Proliferation Heterochromatin Organization Cellular Response To Hypoxia Regulation Of Nucleus Size	Protein Ubiquitination
Pathways
Drugs		Artenimol
Diseases
GWAS		Adventurousness ( 30643258) Cognitive decline rate in late mild cognitive impairment ( 26252872) Morning person ( 30696823) Physical activity (walking duration) ( 30531941)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		5 interacting genes: APP FBXO25 MEOX2 MTDH SUMO2	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		50809	26260
HPRD ID		11026	16439
Ensembl ID		ENSG00000127483	ENSG00000147364
Uniprot IDs		Q5SSJ5	A0A024QZ88 Q8TCJ0
PDB IDs		2RQP
Enriched GO Terms of Interacting Partners?
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