GRN and KRT34

Data Source:
BioGRID (two hybrid)

		GRN	KRT34
Description		granulin precursor	keratin 34
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome	Extracellular Space Cytosol Intermediate Filament
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Chaperone Binding	Structural Molecule Activity Protein Binding
	Biological Process	Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Aspartic-type Peptidase Activity Positive Regulation Of Lysosome Organization	Epidermis Development Keratinization Cornification
Pathways		Neutrophil degranulation	Keratinization Formation of the cornified envelope
Drugs
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		79 interacting genes: ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A MEOX2 NLK NUFIP2 OTX1 P4HB PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SLC13A1 SLPI SMAD9 SMCP SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1	253 interacting genes: A1CF ABHD15 ABI2 ADRA2C AGXT AIMP2 ALDH3B1 AMOT ANKRD11 ANKS1A ARMC7 ASMTL ATG9A ATPAF2 BATF2 BCAS2 BEX1 BEX2 BEX3 BHLHE23 BOLA3 BRME1 C11orf87 C17orf50 C1orf216 C5orf49 CBX8 CCDC120 CCDC13 CCDC146 CCDC196 CCDC198 CCDC24 CCDC28A-AS1 CCHCR1 CCNC CDC20B CDK18 CERK CFAP206 CFAP53 CHRD CHRNG CLCNKA CLDN19 CLEC18A CTRC CWC25 CYSRT1 CYTH4 DCTN3 DDIT4L DDX6 DHRS1 DMRT3 DOCK2 EFCAB3 EIF4G1 EPDR1 EXOC8 EXOSC5 FAM110A FAM214B FAM50B FAM71C FAM83A FAM90A1 FARS2 FBXW5 FNDC11 FOXD4L1 FRS3 GADD45GIP1 GAST GATAD2A GEM GLYCTK GNE GNG10 GNG13 GPS2 GRN GSC2 GSTP1 HAPLN2 HBA1 HBA2 HCK HDAC4 HGS HOXA1 HOXB5 HOXB9 HOXC8 HSPA12B HSPD1 HYAL2 ICAM4 INIP INO80B ISCU ITGB5 ITPKB JOSD1 KANK2 KCTD9 KDELR1 KIDINS220 KLC4 KLHL38 KLK8 KRT1 KRT20 KRT3 KRT6A KRT6C KRT71 KRT74 KRT75 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP12-2 KRTAP13-1 KRTAP19-5 KRTAP19-7 KRTAP26-1 LMO2 LMO4 LRRC29 LRRC41 LYSMD1 LYVE1 MAB21L2 MAD2L2 MAP3K7CL MAPKBP1 MATR3 MBD3L2 METTL17 MIDN MIIP MKRN3 MNS1 MOS MSRB3 MYO15B MYOZ1 MYOZ3 NAB2 NAXD NEK6 NFKBID NMU NOTO NPBWR2 NUP42 P2RX7 PDE9A PDGFRB PGLYRP3 PIN1 PITX1 PITX2 PKN1 PLLP POP5 PPP1R18 PPP1R27 PPP3R2 PRPF18 PRPF31 PRR19 PRR35 PSMA1 PSMB1 PTPMT1 R3HDM2 RAB33A RAB3IL1 RASD1 RFC5 RIN1 RIPPLY1 RTP5 SAMD11 SCNM1 SEC14L4 SEMA4C SHC3 SIRPA SLC15A2 SLC22A5 SLC23A1 SLC25A42 SMARCD1 SMARCE1 SMCP SMG9 SNRPB SPAG8 SPATA46 SPRY3 STMN3 SUOX TACO1 TAPBPL TBC1D22B TCHP TEKT3 TEKT4 TENT5B TEPSIN TFAP2D THAP7 TLE5 TLX3 TMEM174 TMIE TMSB4X TRARG1 TRIM42 TRIM73 TRIML2 TSG101 TTC23 TTC9C TXLNA TXLNB USP2 UTP14C UTP23 VENTX WDR25 WWOX ZDHHC1 ZFHX3 ZFYVE26 ZIC1 ZNF124 ZNF148 ZNF319 ZNF414 ZNF446 ZNF580 ZNF581 ZNF79
Entrez ID		2896	3885
HPRD ID		00733	04137
Ensembl ID		ENSG00000030582	ENSG00000131737
Uniprot IDs		P28799	O76011
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV 6NUG
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?