FBLN5 and LOXL1

Data Source:
BioGRID (pull down, affinity chromatography technology, two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		FBLN5	LOXL1
Description		fibulin 5	lysyl oxidase like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Acrosomal Vesicle Extracellular Region Basement Membrane Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding
	Biological Process	Cell-matrix Adhesion Extracellular Matrix Organization Protein Localization To Cell Surface Secretion Elastic Fiber Assembly Regulation Of Removal Of Superoxide Radicals	Peptidyl-lysine Oxidation Protein Phosphopantetheinylation Protein Deamination Extracellular Matrix Organization Collagen Fibril Organization Response To Lipopolysaccharide Aorta Development
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Elastic fibre formation Crosslinking of collagen fibrils
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)	Adult body size ( 32376654) Aortic root size ( 19584346) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Exfoliation syndrome ( 25706626) Glaucoma (exfoliation) ( 17690259) Hand grip strength ( 29691431) Height ( 28552196 23563607 31562340) Joint mobility (Beighton score) ( 27182965) Pelvic organ prolapse ( 32184442) Pseudoexfoliation syndrome ( 29278698) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		12 interacting genes: ATN1 GFI1B LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PRNP SOD3 TOP3B TRIP13	3 interacting genes: ATXN1 ELN FBLN5
Entrez ID		10516	4016
HPRD ID		05204	08861
Ensembl ID		ENSG00000140092	ENSG00000129038
Uniprot IDs		A0A024R6G3 Q9UBX5	Q08397
PDB IDs
Enriched GO Terms of Interacting Partners?
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