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KPRP and PLA2G10
Data Source:
BioGRID
(two hybrid)
KPRP
PLA2G10
Description
keratinocyte proline rich protein
phospholipase A2 group X
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Extracellular Exosome
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Lysosome
Molecular Function
Protein Binding
1-alkyl-2-acetylglycerophosphocholine Esterase Activity
Phospholipase Activity
Phospholipase A2 Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Phosphatidylserine Metabolic Process
Axon Guidance
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Lipid Storage
Arachidonic Acid Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Prostaglandin Secretion
Low-density Lipoprotein Particle Remodeling
Phosphatidylcholine Catabolic Process
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Cholesterol Homeostasis
Regulation Of Macrophage Activation
Negative Regulation Of DNA-binding Transcription Factor Activity
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidylglycerol Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonic Acid Secretion
Defense Response To Virus
Lysophospholipid Transport
Platelet Activating Factor Catabolic Process
Positive Regulation Of Arachidonic Acid Secretion
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Acrosome Reaction
Pathways
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Drugs
Varespladib methyl
Crotalus adamanteus antivenin
Agkistrodon piscivorus antivenin
Diseases
GWAS
Asthma (
31619474
)
Psoriasis (
25854761
)
Cholesteryl ester levels (
31551469
)
Glycerophospholipid levels (
26068415
)
Interacting Genes
108 interacting genes:
AKAP8L
ANKS1A
ATG9A
BTC
C19orf54
CATSPER1
CCDC57
CES1
CKS1B
CLCNKA
CNFN
CNNM3
COL8A1
CREB5
CYSRT1
DARS1-AS1
DMRT3
DYRK1A
EIF3E
ESR2
FAM221B
FAM72B
FBXO17
FCHO1
FHL2
FHL3
FRS3
GNE
GRAP2
GRB2
GUCD1
HCK
HEXIM2
HNRNPF
HOXA1
HOXC8
HSD3B7
ITGB4
ITIH6
KRTAP1-3
KRTAP1-5
KRTAP10-8
KRTAP12-3
KRTAP13-2
KRTAP13-3
KRTAP15-1
KRTAP19-1
KRTAP19-2
KRTAP19-5
KRTAP19-6
KRTAP19-7
KRTAP3-2
KRTAP4-2
KRTAP4-5
KRTAP5-3
KRTAP5-7
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
LCE3C
LCE3D
LCE3E
LIMS1
LMO2
LNX1
MAPKBP1
MEOX2
MGAT5B
MIIP
MLH1
NBPF19
NCK2
NID2
NOTCH2NLA
NPBWR2
NR4A3
NTN4
NUFIP2
OTX1
PDGFRB
PHLDA1
PLA2G10
PLSCR4
POU4F2
PPIL1
PPP1R32
RANBP3
RBP3
RGL2
RNF38
SEMA3B
SH3KBP1
SLC15A2
SPRED2
SPRY1
SPRY3
STK16
TEKT4
TFAP2D
TNS2
TRIM42
TRIP6
UBASH3A
UBASH3B
VGLL3
VWC2
ZNF587
49 interacting genes:
AGXT
AQP1
ARID5A
ATXN1
BAG3
BEX2
C1orf94
CATSPER1
CCDC120
CREB5
CYSRT1
FAM222B
FOXH1
GATA5
GNE
HGS
HOXC8
HR
HSF4
INCA1
KPRP
KRTAP11-1
KRTAP26-1
LCE1A
LCE1C
LCE2A
LCE2B
LCE2D
MAL
MAPKBP1
MGAT5B
MYO10
NOXA1
NTAQ1
OTX1
PITX1
PLA2R1
POU4F3
PPP1R32
ROR2
SNRPC
SPAG8
STK16
TBX6
TFG
TLX3
VGLL3
VPS37C
ZC3H10
Entrez ID
448834
8399
HPRD ID
18838
04674
Ensembl ID
ENSG00000203786
ENSG00000069764
Uniprot IDs
Q5T749
O15496
PDB IDs
1LE6
1LE7
4UY1
5G3M
5OW8
5OWC
6G5J
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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