Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
KPRP and GNE
Data Source:
BioGRID
(two hybrid)
KPRP
GNE
Description
keratinocyte proline rich protein
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Extracellular Exosome
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
Protein Binding
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Metal Ion Binding
Biological Process
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
Cell Adhesion
Carbohydrate Phosphorylation
Pathways
Sialic acid metabolism
Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM)
Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
GWAS
Asthma (
31619474
)
Psoriasis (
25854761
)
Bipolar disorder (inflammation and infection response interaction) (
25781172
)
Bisphosphonate-associated atypical femoral fracture (
31006051
)
Interacting Genes
108 interacting genes:
AKAP8L
ANKS1A
ATG9A
BTC
C19orf54
CATSPER1
CCDC57
CES1
CKS1B
CLCNKA
CNFN
CNNM3
COL8A1
CREB5
CYSRT1
DARS1-AS1
DMRT3
DYRK1A
EIF3E
ESR2
FAM221B
FAM72B
FBXO17
FCHO1
FHL2
FHL3
FRS3
GNE
GRAP2
GRB2
GUCD1
HCK
HEXIM2
HNRNPF
HOXA1
HOXC8
HSD3B7
ITGB4
ITIH6
KRTAP1-3
KRTAP1-5
KRTAP10-8
KRTAP12-3
KRTAP13-2
KRTAP13-3
KRTAP15-1
KRTAP19-1
KRTAP19-2
KRTAP19-5
KRTAP19-6
KRTAP19-7
KRTAP3-2
KRTAP4-2
KRTAP4-5
KRTAP5-3
KRTAP5-7
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
LCE3C
LCE3D
LCE3E
LIMS1
LMO2
LNX1
MAPKBP1
MEOX2
MGAT5B
MIIP
MLH1
NBPF19
NCK2
NID2
NOTCH2NLA
NPBWR2
NR4A3
NTN4
NUFIP2
OTX1
PDGFRB
PHLDA1
PLA2G10
PLSCR4
POU4F2
PPIL1
PPP1R32
RANBP3
RBP3
RGL2
RNF38
SEMA3B
SH3KBP1
SLC15A2
SPRED2
SPRY1
SPRY3
STK16
TEKT4
TFAP2D
TNS2
TRIM42
TRIP6
UBASH3A
UBASH3B
VGLL3
VWC2
ZNF587
65 interacting genes:
ADAMTSL4
C22orf39
CFP
CRMP1
CYSRT1
ECM1
EGFL7
GRN
GTPBP3
HOXA1
KIAA1549
KPRP
KRT31
KRT34
KRT40
KRT83
KRT85
KRT86
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-3
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-2
KRTAP19-7
KRTAP3-1
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-4
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
MDFI
MGAT5B
NBPF19
NID2
NOTCH2NLA
PLA2G10
PRICKLE4
RIF1
SPRY1
SPRY2
SPRY3
SSC4D
TRIM27
TRIM42
TRIP6
TSPAN4
VWC2
WDR83
WWOX
ZBTB16
Entrez ID
448834
10020
HPRD ID
18838
04825
Ensembl ID
ENSG00000203786
ENSG00000159921
Uniprot IDs
Q5T749
Q9Y223
PDB IDs
2YHW
2YHY
2YI1
3EO3
4ZHT
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?