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F11R and ITGAL
Data Source:
HPRD
(in vivo, two hybrid)
F11R
ITGAL
Description
F11 receptor
integrin subunit alpha L
Image
GO Annotations
Cellular Component
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Integral Component Of Membrane
Cell Junction
Cytoplasmic Vesicle
Protein-containing Complex
Slit Diaphragm
Extracellular Exosome
Tight Junction
Plasma Membrane
Integrin Complex
Cell Surface
Membrane
Integrin AlphaL-beta2 Complex
Specific Granule Membrane
Extracellular Exosome
Molecular Function
Virus Receptor Activity
Integrin Binding
Protein Binding
PDZ Domain Binding
Protein Homodimerization Activity
Cadherin Binding
Protein Binding
ICAM-3 Receptor Activity
Protein-containing Complex Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Biological Process
Regulation Of Cytokine Production
Inflammatory Response
Leukocyte Cell-cell Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cell Shape
Response To Radiation
Extracellular Matrix Organization
Actomyosin Structure Organization
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of GTPase Activity
Positive Regulation Of Rho Protein Signal Transduction
Maintenance Of Blood-brain Barrier
Memory T Cell Extravasation
Positive Regulation Of GTPase Activity
Positive Regulation Of Blood Pressure
Viral Entry Into Host Cell
Intestinal Absorption
Leukocyte Migration
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Bicellular Tight Junction Assembly
Cellular Response To Mechanical Stimulus
Protein Localization To Plasma Membrane
Establishment Of Endothelial Intestinal Barrier
Regulation Of Membrane Permeability
Cell-cell Adhesion
Positive Regulation Of Platelet Aggregation
Protein Localization To Bicellular Tight Junction
Positive Regulation Of Establishment Of Endothelial Barrier
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Bicellular Tight Junction Assembly
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Phagocytosis
Inflammatory Response
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Viral Process
Extracellular Matrix Organization
Memory T Cell Extravasation
Receptor Clustering
Neutrophil Degranulation
Regulation Of Immune Response
Leukocyte Migration
Cell-cell Adhesion
Pathways
Cell surface interactions at the vascular wall
Integrin cell surface interactions
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Neutrophil degranulation
RUNX3 Regulates Immune Response and Cell Migration
Drugs
Efalizumab
Antithymocyte immunoglobulin (rabbit)
Lovastatin
Simvastatin
Rosuvastatin
1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine
LFA703
(S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamide
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile
3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
Pitavastatin
Lifitegrast
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Night sleep phenotypes (
27126917
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte count (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
27863252
)
Smooth-surface caries (
24556642
)
Ulcerative colitis (
28067908
23128233
)
White blood cell count (
32888494
27863252
)
Interacting Genes
30 interacting genes:
AFDN
ASIP
BDNF
CAMLG
CASK
CGN
CSNK2A1
F2RL2
ITGAL
JAGN1
MARCHF2
MMP14
MPDZ
MYADM
PARD3
PEX19
PGAP2
PICK1
PRKCA
PTPRB
RABAC1
SGTA
SLC30A2
SLC35A1
SNAP47
STRIT1
TJP1
TMEM100
TMEM147
TMEM86B
7 interacting genes:
F11R
ICAM1
ICAM3
ICAM5
PTPRC
RANBP9
SHARPIN
Entrez ID
50848
3683
HPRD ID
12038
01079
Ensembl ID
ENSG00000158769
ENSG00000005844
Uniprot IDs
Q6FIB4
Q9Y624
B2RAL6
P20701
PDB IDs
1NBQ
3EOY
3TSZ
4ODB
1CQP
1DGQ
1IJ4
1LFA
1MJN
1MQ8
1MQ9
1MQA
1RD4
1T0P
1XDD
1XDG
1XUO
1ZON
1ZOO
1ZOP
2ICA
2K8O
2M3E
2O7N
3BN3
3BQM
3BQN
3E2M
3EOA
3EOB
3F74
3F78
3HI6
3M6F
3TCX
4IXD
5E6R
5E6S
5E6U
6BXB
6BXF
6BXJ
6CKB
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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