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MDH1 and HSD17B10
Data Source:
BioGRID
(two hybrid)
MDH1
HSD17B10
Description
malate dehydrogenase 1
hydroxysteroid 17-beta dehydrogenase 10
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Centrosome
Cytosol
Extracellular Exosome
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Plasma Membrane
Mitochondrial Ribonuclease P Complex
Mitochondrial Nucleoid
Molecular Function
Malic Enzyme Activity
Protein Binding
L-malate Dehydrogenase Activity
Diiodophenylpyruvate Reductase Activity
TRNA Binding
RNA Binding
3-hydroxyacyl-CoA Dehydrogenase Activity
Protein Binding
Cholate 7-alpha-dehydrogenase Activity
Testosterone Dehydrogenase [NAD(P)] Activity
17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Testosterone Dehydrogenase (NAD+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Biological Process
Gluconeogenesis
Tricarboxylic Acid Cycle
Oxaloacetate Metabolic Process
Malate Metabolic Process
NADH Metabolic Process
Isoleucine Catabolic Process
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Bile Acid Biosynthetic Process
Mitochondrion Organization
C21-steroid Hormone Metabolic Process
Androgen Metabolic Process
Estrogen Metabolic Process
Branched-chain Amino Acid Catabolic Process
Protein Homotetramerization
Brexanolone Metabolic Process
Mitochondrial TRNA Methylation
Mitochondrial TRNA Processing
Mitochondrial TRNA 5'-end Processing
Mitochondrial TRNA 3'-end Processing
Pathways
Gluconeogenesis
tRNA processing in the mitochondrion
tRNA modification in the mitochondrion
Branched-chain amino acid catabolism
rRNA processing in the mitochondrion
Drugs
NADH
Nicotinamide adenine dinucleotide phosphate
Artenimol
NADH
1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Omega-3-carboxylic acids
Diseases
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
Non-syndromic X-linked mental retardation
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Asthma and attention deficit hyperactivity disorder (
31619474
)
Blood protein levels (
30072576
)
Smoking status (ever vs never smokers) (
30643258
)
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Interacting Genes
14 interacting genes:
CDC42
CHRM2
EGFR
ERBB2
FUS
GPD1
HSD17B10
HSPB2
LTB4R2
MPP3
SERPINB5
TERF1
TERF2IP
TP53
32 interacting genes:
ALDH3B1
ALDOA
APP
ATP5F1A
CDC42
CHD3
CPS1
CS
ETFDH
FAF1
GLUD1
GLUL
HADHA
HADHB
HMGCL
HMGCS2
HTRA2
MDH1
OGDH
PDHA1
PDHB
PDHX
PRKN
PTEN
PYGL
TOMM20
TOMM22
TOMM40
TRAF3IP2
TRAF5
TRAF6
UBE2D1
Entrez ID
4190
3028
HPRD ID
01100
02223
Ensembl ID
ENSG00000014641
ENSG00000072506
Uniprot IDs
A0A5K1VW95
P40925
V9HWF2
A0A0S2Z410
Q99714
PDB IDs
1F67
1SO8
1U7T
2O23
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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