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SMAD2 and RASA1
Data Source:
BioGRID
(two hybrid)
SMAD2
RASA1
Description
SMAD family member 2
RAS p21 protein activator 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Transcription Factor Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Type I Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
Phosphotyrosine Residue Binding
GTPase Activity
GTPase Activator Activity
Signaling Receptor Binding
Protein Binding
Potassium Channel Inhibitor Activity
GTPase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
SMAD Protein Complex Assembly
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Anterior/posterior Pattern Specification
Positive Regulation Of Epithelial To Mesenchymal Transition
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Insulin Secretion
Cell Differentiation
Lung Development
Adrenal Gland Development
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Wound Healing
Cell Fate Commitment
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Binding
Pericardium Development
SMAD Protein Signal Transduction
Secondary Palate Development
Response To Cholesterol
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
MAPK Cascade
Mitotic Cytokinesis
Vasculogenesis
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Cell Adhesion
Signal Transduction
Regulation Of Cell Shape
Regulation Of Actin Filament Polymerization
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Ras Protein Signal Transduction
Ephrin Receptor Signaling Pathway
Blood Vessel Morphogenesis
Regulation Of RNA Metabolic Process
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Downstream signal transduction
EPHB-mediated forward signaling
EPHB-mediated forward signaling
VEGFR2 mediated cell proliferation
Regulation of RAS by GAPs
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Dexfosfoserine
Diseases
Colorectal cancer
RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS
Coronary artery disease in type 1 diabetes (
29695241
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Chronotype (
30696823
)
Macular thickness (
30535121
)
Major depressive disorder (
23377640
)
Openness (
21173776
)
Prostate cancer aggressiveness (
25939597
)
Type 2 diabetes (
30297969
)
Interacting Genes
219 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
94 interacting genes:
ABL1
AFAP1L2
ANXA6
APC
APP
AR
ARHGAP1
ARHGAP5
AURKA
AURKB
BBS10
BCL10
BCR
BIRC5
BMPR1A
BUB1
CASP3
CASP7
CAV2
CD5
CDKN2A
CSF1R
CSK
DCC
DLC1
DNAJA3
DOK1
DOK2
DOK4
EGFR
EIF1
EPHA2
EPHB2
EPHB3
ERBB2
ERBB3
ERBB4
EZH2
FES
FGFR1
G3BP1
GAB1
GMCL1
GRB2
HCK
HRAS
HSPD1
HTT
IGF1R
INSR
KDR
KHDRBS1
KIT
LCK
LYN
MAGI1
MAP4K4
MET
MLH3
NCK1
NRAS
NTRK1
OLIG1
PAG1
PDE6D
PDGFRB
PIK3R1
PMS2
PTK2B
PTPRC
PTPRJ
PXN
RAB5A
RACK1
RAP1A
RB1
SERPINA4
SHC1
SLC9A2
SMAD2
SOCS3
SPSB1
SRC
STAU1
STK11
SYK
SYN1
TRMT2A
WWP1
WWP2
XRCC6
YES1
ZAP70
ZNF579
Entrez ID
4087
5921
HPRD ID
03221
00745
Ensembl ID
ENSG00000175387
ENSG00000145715
Uniprot IDs
B7Z5N5
Q15796
Q53XR6
P20936
Q59GK3
PDB IDs
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
1WER
1WQ1
2GQI
2GSB
2J05
2J06
2M51
4FSS
6PXB
6PXC
6WAX
6WAY
Enriched GO Terms of Interacting Partners
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