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SMAD2 and LMO2
Data Source:
HPRD
(in vivo)
SMAD2
LMO2
Description
SMAD family member 2
LIM domain only 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Nucleoplasm
Transcription Regulator Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Transcription Factor Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Type I Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
RNA Polymerase II Activating Transcription Factor Binding
Transcription Coregulator Binding
Transcription Coactivator Activity
Protein Binding
BHLH Transcription Factor Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
SMAD Protein Complex Assembly
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Anterior/posterior Pattern Specification
Positive Regulation Of Epithelial To Mesenchymal Transition
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Insulin Secretion
Cell Differentiation
Lung Development
Adrenal Gland Development
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Wound Healing
Cell Fate Commitment
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Binding
Pericardium Development
SMAD Protein Signal Transduction
Secondary Palate Development
Response To Cholesterol
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Multicellular Organism Development
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Thyroid Hormone Stimulus
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Dexfosfoserine
Diseases
Colorectal cancer
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS
Coronary artery disease in type 1 diabetes (
29695241
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Cognitive performance (
19734545
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Iron status biomarkers (transferrin saturation) (
28334935
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
27863252
)
Interacting Genes
219 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
188 interacting genes:
ABI2
ADAMTSL4
AFDN
AGTRAP
AIMP2
ALDH6A1
ARHGEF5
ARID5A
ARNT2
AXIN1
BANP
BCAS2
BEX2
BLZF1
BYSL
C1orf109
C1orf94
CALCOCO2
CBY2
CCDC33
CDC25A
CDC5L
CDX4
CLHC1
CMTM5
CORO1A
CORO1C
DAZAP2
DBF4B
DDIT3
DMRT3
DRAP1
DYDC1
EFHC1
EFHC2
EHMT2
EIF3B
EIF4EBP1
ELF2
ENKD1
ERBIN
FAAP20
FAM214B
FAM228A
FAM90A1
FHL3
FHL5
GAS8
GATA1
GATA2
GATA3
GFAP
GMEB2
GOLGA2
GRB2
HDAC5
HNRNPC
HNRNPM
HOOK1
ICA1L
IFT43
IHO1
IKZF1
IKZF3
INCA1
ISL1
ISY1
KANK2
KAZN
KDM5A
KIF2A
KIF3B
KPRP
KRT15
KRT34
KRT40
KRT75
KRT80
KRTAP10-7
LDB1
LDB2
LDOC1
LMO4
LMOD3
LYL1
LZTS1
LZTS2
MAGEA8
MAPRE1
MAPRE2
MAPRE3
MBIP
MISP
MRFAP1L1
MSN
MTUS2
MYOZ3
N4BP2L2
NCAPH2
NDOR1
NDUFAB1
NDUFB7
NFKBID
NHLH1
NIF3L1
NOTCH2NLA
NOXA1
NSMF
NTAQ1
NUP62
NUTM1
PATZ1
PAX9
PBX4
PDE9A
PHC2
POLR2G
PPP1R32
PRDM6
PRKG1
PSMA1
RBBP8
RCN1
REL
RELA
RINT1
RLIM
ROCK1
RTL8C
RUSC1
SAXO1
SGTB
SKP1
SMAD2
SMUG1
SNAPC5
SOX5
SP1
SSX2IP
STAT1
STAT3
STIP1
TAL1
TAL2
TBX2
TCP10L
TEKT3
TFIP11
TFPT
THAP6
TLE5
TLX3
TRIB3
TRIM23
TRIM54
TRIM55
TRIM63
TRIP6
TSC1
TSC22D4
TSEN15
TSEN54
TSGA10IP
TSPYL2
TSSK3
TUFT1
UBA6
UBASH3B
UBE2I
USH1G
VBP1
VEZF1
VMAC
WASF1
WASHC1
YOD1
YPEL3
ZFP64
ZMYND12
ZNF185
ZNF19
ZNF24
ZNF250
ZNF34
ZNF410
ZNF641
ZNF655
ZNF688
Entrez ID
4087
4005
HPRD ID
03221
01586
Ensembl ID
ENSG00000175387
ENSG00000135363
Uniprot IDs
B7Z5N5
Q15796
Q53XR6
P25791
PDB IDs
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
2XJY
2XJZ
2YPA
4KFZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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