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SMAD2 and PRKAR1A
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SMAD2
PRKAR1A
Description
SMAD family member 2
protein kinase cAMP-dependent type I regulatory subunit alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Immunological Synapse
Cytoplasm
Multivesicular Body
Centrosome
Cytosol
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nucleotide-activated Protein Kinase Complex
Neuromuscular Junction
Protein-containing Complex
Plasma Membrane Raft
Sperm Connecting Piece
Ciliary Base
Glutamatergic Synapse
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Transcription Factor Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Type I Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
CAMP-dependent Protein Kinase Regulator Activity
Protein Domain Specific Binding
CAMP Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
SMAD Protein Complex Assembly
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Anterior/posterior Pattern Specification
Positive Regulation Of Epithelial To Mesenchymal Transition
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Insulin Secretion
Cell Differentiation
Lung Development
Adrenal Gland Development
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Wound Healing
Cell Fate Commitment
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Binding
Pericardium Development
SMAD Protein Signal Transduction
Secondary Palate Development
Response To Cholesterol
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Mesoderm Formation
Renal Water Homeostasis
Regulation Of Transcription By RNA Polymerase II
Female Meiotic Nuclear Division
Blood Coagulation
Regulation Of Protein Kinase A Signaling
Activation Of Protein Kinase A Activity
Intracellular Signal Transduction
Regulation Of CAMP-mediated Signaling
Sarcomere Organization
Negative Regulation Of Meiotic Nuclear Division
Negative Regulation Of Activated T Cell Proliferation
Cardiac Muscle Cell Proliferation
Cellular Response To Glucagon Stimulus
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
CREB1 phosphorylation through the activation of Adenylate Cyclase
Hedgehog 'off' state
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
Drugs
Dexfosfoserine
(Rp)-cAMPS
Cyclic GMP
Cyclic adenosine monophosphate
GEM-231
Diseases
Colorectal cancer
Pigmented micronodular adrenocortical disease (PPNAD)
GWAS
Coronary artery disease in type 1 diabetes (
29695241
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Body size at age 10 (
32376654
)
Coronary artery disease (
33020668
)
Estimated glomerular filtration rate (
31152163
)
Intake of total sugars (
31005972
)
Interacting Genes
219 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
47 interacting genes:
AKAP1
AKAP10
AKAP11
AKAP4
AKAP5
AKAP7
ARFGEF2
BAHD1
C11orf49
C2orf88
CAPN11
CBS
CCNE1
CDK2
CDK4
DTX1
EGFR
FAM153B
GRB2
HIVEP1
HLA-A
ITGA4
MAPK6
MYO7A
NELL2
PATZ1
PJA2
PLEKHF2
PRKACA
PRKAR1B
PRKX
PRPF40A
PYCARD
RAF1
RFC2
RSPH3
SET
SETD7
SLC2A4
SMAD2
SPART
TAB1
TULP3
WDCP
WNK1
YWHAZ
ZBED1
Entrez ID
4087
5573
HPRD ID
03221
01786
Ensembl ID
ENSG00000175387
ENSG00000108946
Uniprot IDs
B7Z5N5
Q15796
Q53XR6
B2R5T5
P10644
PDB IDs
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
5KJX
5KJY
5KJZ
Enriched GO Terms of Interacting Partners
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