SMAD2 and GTF2I

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SMAD2	GTF2I
Description		SMAD family member 2	general transcription factor IIi
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Activin Responsive Factor Complex Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Transcription Factor Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Type I Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Tau Protein Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Disordered Domain Specific Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly Zygotic Specification Of Dorsal/ventral Axis Gastrulation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Cell Differentiation Lung Development Adrenal Gland Development BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Wound Healing Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Binding Pericardium Development SMAD Protein Signal Transduction Secondary Palate Development Response To Cholesterol Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry	Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Repair By Transcription From RNA Polymerase II Promoter
Pathways		Signaling by NODAL Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
Drugs		Dexfosfoserine
Diseases		Colorectal cancer
GWAS		Coronary artery disease in type 1 diabetes ( 29695241) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 27182965)	Atrial fibrillation ( 30061737 29892015) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) SjÃ¶gren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469)
Interacting Genes		219 interacting genes: ABTB1 ACVR1B AFDN AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5ME AXIN1 BAZ1A BECN1 BPTF BRCA1 BTBD2 C22orf46 CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CORO2A CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYLC2 CYP11A1 DAB2 DCAF6 DCUN1D1 DENND2B DNAJB5 DNAJC7 DOCK8 DVL1 DYNC1H1 E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBIN ESR1 ESR2 FAM161B FBN2 FBP2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HSD17B3 HUWE1 HYAL2 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KPNB1 LAMA5 LATS2 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAP2K1 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NFIA NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASA1 RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TRMO TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X WASHC4 XPA YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF510 ZNF8 ZNHIT6	46 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 YY1 ZBTB17 ZMYM3
Entrez ID		4087	2969
HPRD ID		03221	03399
Ensembl ID		ENSG00000175387	ENSG00000263001
Uniprot IDs		B7Z5N5 Q15796 Q53XR6	A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09
PDB IDs		1DEV 1KHX 1U7V 2LB3 5XOD 5ZOJ 6H3R	2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?
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