RASA1 and PMS2

Data Source:
BioGRID (two hybrid)

		RASA1	PMS2
Description		RAS p21 protein activator 1	PMS1 homolog 2, mismatch repair system component
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytosol Plasma Membrane Mismatch Repair Complex MutLalpha Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding
	Biological Process	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process	Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)	Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		94 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NRAS NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	16 interacting genes: AKT1 ANP32B CCDC180 EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC XPA ZNF189
Entrez ID		5921	5395
HPRD ID		00745	02598
Ensembl ID		ENSG00000145715	ENSG00000122512
Uniprot IDs		P20936 Q59GK3	A0A2R8Y6S3 B4DGM0 C9J167 P54278 Q7Z3Q2
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY	1EA6 1H7S 1H7U 5U5R 6MFQ
Enriched GO Terms of Interacting Partners?
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