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MIR145 and KARS1
Data Source:
BioGRID
(unspecified method)
MIR145
KARS1
Description
microRNA 145
lysyl-tRNA synthetase 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Exosome
Extracellular Space
Nucleus
Mitochondrion
Mitochondrial Matrix
Cytosol
Plasma Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Molecular Function
RNA Polymerase II Complex Binding
MRNA 3'-UTR Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
TRNA Binding
ATP Adenylyltransferase Activity
Lysine-tRNA Ligase Activity
Protein Binding
ATP Binding
Amino Acid Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Regulation Of Smooth Muscle Contraction
Negative Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Ectodermal Cell Differentiation
Positive Regulation Of Fibroblast Migration
Negative Regulation Of Angiogenesis
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Negative Regulation Of Interleukin-16 Production
Positive Regulation Of Interleukin-10 Production
Regulation Of Collagen Biosynthetic Process
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Vascular Associated Smooth Muscle Cell Differentiation
Myofibroblast Differentiation
Angiotensin-activated Signaling Pathway
Positive Regulation Of Macrophage Activation
Establishment Or Maintenance Of Cell Type Involved In Phenotypic Switching
Positive Regulation Of Macrophage Differentiation
Mesodermal Cell Differentiation
Negative Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Negative Regulation Of Protein Kinase B Signaling
Aorta Smooth Muscle Tissue Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Phenotypic Switching
Negative Regulation Of Somatic Stem Cell Population Maintenance
Negative Regulation Of Somatic Stem Cell Division
Negative Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation
Basophil Activation Involved In Immune Response
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
TRNA Aminoacylation For Protein Translation
Lysyl-tRNA Aminoacylation
TRNA Processing
Response To X-ray
Diadenosine Tetraphosphate Biosynthetic Process
Viral Process
Positive Regulation Of Macrophage Activation
Positive Regulation Of Transcription, DNA-templated
ERK1 And ERK2 Cascade
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Mitochondrial tRNA aminoacylation
Drugs
L-Lysine
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Interacting Genes
79 interacting genes:
ADARB1
APOBEC3B
AQR
C1QBP
DARS1
DDX1
DDX21
DDX3X
DHX36
EIF2AK2
EPRS1
ERAL1
FAM98A
FUS
G3BP2
HARS2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KNOP1
LARP6
LARP7
LIN28A
LIN28B
LRPPRC
MARS1
MATR3
MSI2
NONO
NUDT16L1
NUDT21
PDCD11
PGAM5
PRMT1
PTBP1
PTBP3
PUF60
PUM1
RARS1
RBM14
RBM4
RTCA
RTCB
SF3A1
SF3A3
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
STRBP
SYNCRIP
TAF15
TENT2
TIAL1
TRA2A
TRA2B
U2SURP
UPF1
UTP20
YBX1
YBX3
ZFR
ZNF346
84 interacting genes:
AIMP2
CDC42
DARS2
DYSF
EEF1D
EEF1G
ESR1
FRS3
GAPDH
GEMIN4
LINC01554
MAPK1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-2
MIR18B
MIR199A1
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR25
MIR29A
MIR29B1
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
PAFAH1B1
PIK3R3
RPSA
SLC25A6
SOD1
SPTAN1
SUMO2
VIM
Entrez ID
406937
3735
HPRD ID
03249
Ensembl ID
ENSG00000276365
ENSG00000065427
Uniprot IDs
Q15046
PDB IDs
3BJU
4DPG
4YCU
4YCW
6CHD
6ILD
6ILH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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