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KARS1 and RPSA
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
KARS1
RPSA
Description
lysyl-tRNA synthetase 1
ribosomal protein SA
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Mitochondrion
Mitochondrial Matrix
Cytosol
Plasma Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytosolic Small Ribosomal Subunit
Extracellular Exosome
Molecular Function
TRNA Binding
ATP Adenylyltransferase Activity
Lysine-tRNA Ligase Activity
Protein Binding
ATP Binding
Amino Acid Binding
Identical Protein Binding
Protein Homodimerization Activity
Virus Receptor Activity
RNA Binding
Structural Constituent Of Ribosome
Laminin Receptor Activity
Protein Binding
Ribosome Binding
Laminin Binding
Biological Process
Basophil Activation Involved In Immune Response
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
TRNA Aminoacylation For Protein Translation
Lysyl-tRNA Aminoacylation
TRNA Processing
Response To X-ray
Diadenosine Tetraphosphate Biosynthetic Process
Viral Process
Positive Regulation Of Macrophage Activation
Positive Regulation Of Transcription, DNA-templated
ERK1 And ERK2 Cascade
Ribosomal Small Subunit Assembly
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cytoplasmic Translation
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Cell Adhesion
Viral Transcription
Viral Entry Into Host Cell
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Mitochondrial tRNA aminoacylation
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
L-Lysine
Tigapotide
Copper
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Dentate gyrus volume x schizophrenia interaction (
31155012
)
Interacting Genes
84 interacting genes:
AIMP2
CDC42
DARS2
DYSF
EEF1D
EEF1G
ESR1
FRS3
GAPDH
GEMIN4
LINC01554
MAPK1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-2
MIR18B
MIR199A1
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR25
MIR29A
MIR29B1
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
PAFAH1B1
PIK3R3
RPSA
SLC25A6
SOD1
SPTAN1
SUMO2
VIM
31 interacting genes:
ABCD1
ACADVL
ACD
ANKH
CALM2
CBX5
CCDC13
CLEC4G
CSF2RA
DCTN6
GNMT
HBG2
HNRNPD
HSPB1
IL7R
ILRUN
ITGA6
KARS1
LAMA2
LINC01554
NKX3-1
PEA15
POT1
PRND
PROS1
RNF114
RPS21
SLC2A5
SUMO4
TINF2
TRIB3
Entrez ID
3735
3921
HPRD ID
03249
01038
Ensembl ID
ENSG00000065427
ENSG00000168028
Uniprot IDs
Q15046
A0A024R2L6
A0A0C4DG17
P08865
PDB IDs
3BJU
4DPG
4YCU
4YCW
6CHD
6ILD
6ILH
3BCH
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6EK0
6FEC
6G18
6G4S
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBD
6YBW
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOK
6ZON
6ZP4
6ZVH
6ZVJ
7A09
7K5I
Enriched GO Terms of Interacting Partners
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