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KARS1 and MAPK1
Data Source:
BioGRID
(enzymatic study)
KARS1
MAPK1
Description
lysyl-tRNA synthetase 1
mitogen-activated protein kinase 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Mitochondrion
Mitochondrial Matrix
Cytosol
Plasma Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Postsynaptic Density
Axon
Pseudopodium
Dendrite Cytoplasm
Protein-containing Complex
Azurophil Granule Lumen
Perikaryon
Mitotic Spindle
Ficolin-1-rich Granule Lumen
Molecular Function
TRNA Binding
ATP Adenylyltransferase Activity
Lysine-tRNA Ligase Activity
Protein Binding
ATP Binding
Amino Acid Binding
Identical Protein Binding
Protein Homodimerization Activity
Phosphotyrosine Residue Binding
Double-stranded DNA Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Identical Protein Binding
Biological Process
Basophil Activation Involved In Immune Response
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
TRNA Aminoacylation For Protein Translation
Lysyl-tRNA Aminoacylation
TRNA Processing
Response To X-ray
Diadenosine Tetraphosphate Biosynthetic Process
Viral Process
Positive Regulation Of Macrophage Activation
Positive Regulation Of Transcription, DNA-templated
ERK1 And ERK2 Cascade
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Protein Phosphorylation
Apoptotic Process
Chemotaxis
Cellular Response To DNA Damage Stimulus
Cell Cycle
Signal Transduction
Cell Surface Receptor Signaling Pathway
Chemical Synaptic Transmission
Axon Guidance
Aging
Learning Or Memory
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Phosphatidylinositol 3-kinase Signaling
Diadenosine Tetraphosphate Biosynthetic Process
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cytosine Metabolic Process
Platelet Activation
Regulation Of Ossification
Regulation Of Cellular PH
Thyroid Gland Development
Regulation Of Protein Stability
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Mammary Gland Epithelial Cell Proliferation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Response To Nicotine
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Outer Ear Morphogenesis
Neutrophil Degranulation
Response To Exogenous DsRNA
Response To Estrogen
Negative Regulation Of Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Decidualization
Thymus Development
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Long-term Synaptic Potentiation
Face Development
Lung Morphogenesis
Trachea Formation
Labyrinthine Layer Blood Vessel Development
Cardiac Neural Crest Cell Development Involved In Heart Development
ERK1 And ERK2 Cascade
Response To Epidermal Growth Factor
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Macrophage Proliferation
Regulation Of Cellular Response To Heat
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Regulation Of Early Endosome To Late Endosome Transport
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Mitochondrial tRNA aminoacylation
phospho-PLA2 pathway
RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Spry regulation of FGF signaling
Golgi Cisternae Pericentriolar Stack Reorganization
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-stimulated signaling through PRKCZ
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by MAPK mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
Drugs
L-Lysine
Acetylsalicylic acid
Minocycline
Isoprenaline
Arsenic trioxide
Olomoucine
Phosphonothreonine
Purvalanol
SB220025
Seliciclib
Perifosine
N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
(1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione
[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine
Turpentine
Ulixertinib
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Bipolar disorder (
31043756
)
Body size at age 10 (
32376654
)
Inflammatory bowel disease (
23128233
)
Multiple sclerosis (
31604244
24076602
21833088
)
Superior parietal cortex volume (
31530798
)
Interacting Genes
84 interacting genes:
AIMP2
CDC42
DARS2
DYSF
EEF1D
EEF1G
ESR1
FRS3
GAPDH
GEMIN4
LINC01554
MAPK1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-2
MIR18B
MIR199A1
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR25
MIR29A
MIR29B1
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
PAFAH1B1
PIK3R3
RPSA
SLC25A6
SOD1
SPTAN1
SUMO2
VIM
248 interacting genes:
AR
ARRB1
ARRB2
ATF2
ATP1A1
BANP
BCL2
BCL3
BCL6
BRAF
C1QBP
CACYBP
CAD
CALCOCO1
CAPN2
CASP8
CASP9
CAV1
CD19
CDC25C
CDX2
CEBPB
CEP55
CHN1
CITED2
CMTM3
COPS6
CREBBP
CRP
CSNK2A1
CTNND1
CTSD
CUEDC2
DAPK1
DUSP1
DUSP16
DUSP2
DUSP3
DUSP4
DUSP5
DUSP6
DUSP7
DUSP9
DYRK1B
EGFR
EGLN3
EIF4EBP1
ELK1
ELK4
ENAH
EP300
EPOR
ERF
ESR1
ESR2
ETS1
FCGR2B
FHL3
FOS
FOXO3
FRS2
FRS3
GAB1
GAB2
GABRR1
GAPDH
GATA1
GATA2
GATA4
GJA1
GMFB
GNPTAB
GORASP2
GRB10
GRB2
GSK3B
HDAC4
HDAC6
HIF1A
HNF4A
HOMEZ
HSF1
HSF4
HSP90AA1
ID2
IER3
IFI35
IFNAR1
IQGAP1
IRS1
ITGB6
JUN
JUND
KARS1
KDR
KHDRBS1
KLF11
KRT8
KSR1
KSR2
LAMTOR3
LCK
LIFR
LIPE
LRPAP1
LRRC4
LZTS2
MAFA
MAP2K1
MAP2K2
MAP2K4
MAP2K6
MAP2K7
MAP3K1
MAP3K10
MAPK14
MAPK8
MAPKAPK5
MAPT
MBP
MCL1
MDFI
METAP2
MITF
MKNK1
MKNK2
MSX2
MTIF3
MTPN
MYB
MYC
NCOA1
NCOA3
NDE1
NEFH
NEK2
NGFR
NKX2-1
NOXA1
NR3C1
NR4A1
NR4A2
NR5A1
NRL
NTRK3
NUP153
PAK1
PAK2
PAX5
PDE4D
PEA15
PEBP1
PKM
PLA2G4A
PLAGL2
PLAT
PLCB1
PLK3
POLR2G
PPARA
PPARG
PPP1CA
PPP1R18
PPP1R9B
PPP2CA
PPP2R5B
PPP2R5C
PRDX6
PRKCD
PRKCE
PRKCZ
PRPSAP1
PSMA1
PTPDC1
PTPN1
PTPN5
PTPN7
PTPRC
PTPRE
PTPRH
PTPRR
PXN
RAF1
RB1
REST
RET
RGS19
RNF216
RNF8
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RUNX1
RXRA
SCNN1G
SH2D3C
SHANK3
SHC1
SLC9A1
SMAD1
SMAD2
SMAD3
SMAD4
SNCA
SNCG
SORBS3
SOS1
SP1
SREBF1
SREBF2
STAT3
STAT5A
STAT5B
STXBP1
STYX
SUPT20H
TCF3
TFCP2
TGIF1
TH
TIAL1
TLE5
TNFRSF1A
TNFRSF25
TNFSF11
TNIP1
TNIP2
TNKS2
TOB1
TOP2A
TP53
TPR
TSC2
TTN
TXNIP
UBE3A
UBR5
UBTF
VAV1
VDR
YBX1
YBX3
ZBTB42
ZC3HC1
ZFP36
Entrez ID
3735
5594
HPRD ID
03249
01496
Ensembl ID
ENSG00000065427
ENSG00000100030
Uniprot IDs
Q15046
P28482
Q1HBJ4
Q499G7
PDB IDs
3BJU
4DPG
4YCU
4YCW
6CHD
6ILD
6ILH
1PME
1TVO
1WZY
2OJG
2OJI
2OJJ
2Y9Q
3D42
3D44
3I5Z
3I60
3SA0
3TEI
3W55
4FMQ
4FUX
4FUY
4FV0
4FV1
4FV2
4FV3
4FV4
4FV5
4FV6
4FV7
4FV8
4FV9
4G6N
4G6O
4H3P
4H3Q
4IZ5
4IZ7
4IZA
4N0S
4NIF
4O6E
4QP1
4QP2
4QP3
4QP4
4QP6
4QP7
4QP8
4QP9
4QPA
4QTA
4QTE
4XJ0
4ZXT
4ZZM
4ZZN
4ZZO
5AX3
5BUE
5BUI
5BUJ
5BVD
5BVE
5BVF
5K4I
5LCJ
5LCK
5NGU
5NHF
5NHH
5NHJ
5NHL
5NHO
5NHP
5NHV
5V60
5V61
5V62
5WP1
6D5Y
6DMG
6G54
6G8X
6G91
6G92
6G93
6G97
6G9A
6G9D
6G9H
6G9J
6G9K
6G9M
6G9N
6GDM
6GDQ
6GE0
6GJB
6GJD
6NBS
6OPG
6OPH
6OPI
6Q7K
6Q7S
6Q7T
6QA1
6QA3
6QA4
6QAG
6QAH
6QAL
6QAQ
6QAW
6RQ4
6SLG
Enriched GO Terms of Interacting Partners
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