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KARS1 and MIR29B1
Data Source:
BioGRID
(unspecified method)
KARS1
MIR29B1
Description
lysyl-tRNA synthetase 1
microRNA 29b-1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Mitochondrion
Mitochondrial Matrix
Cytosol
Plasma Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Extracellular Exosome
Extracellular Vesicle
Molecular Function
TRNA Binding
ATP Adenylyltransferase Activity
Lysine-tRNA Ligase Activity
Protein Binding
ATP Binding
Amino Acid Binding
Identical Protein Binding
Protein Homodimerization Activity
MRNA 3'-UTR Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
Biological Process
Basophil Activation Involved In Immune Response
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
TRNA Aminoacylation For Protein Translation
Lysyl-tRNA Aminoacylation
TRNA Processing
Response To X-ray
Diadenosine Tetraphosphate Biosynthetic Process
Viral Process
Positive Regulation Of Macrophage Activation
Positive Regulation Of Transcription, DNA-templated
ERK1 And ERK2 Cascade
Negative Regulation Of Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Collagen Biosynthetic Process
Negative Regulation Of Type III Interferon Production
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Positive Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of DNA Methylation
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Protein Secretion
Negative Regulation Of Protein Kinase B Signaling
Regulation Of Blood Vessel Remodeling
Negative Regulation Of Circulating Fibrinogen Levels
Negative Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Virus
Negative Regulation Of Interleukin-32 Production
Negative Regulation Of Extracellular Matrix Assembly
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Negative Regulation Of Amyloid-beta Formation
Negative Regulation Of Mesenchymal Stem Cell Proliferation
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Oxidative Stress-induced Cell Death
Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Aorta Morphogenesis
Negative Regulation Of Collagen Fibril Organization
Negative Regulation Of Matrix Metallopeptidase Secretion
Positive Regulation Of Metalloendopeptidase Activity
Regulation Of Epithelium Regeneration
Negative Regulation Of Metallopeptidase Activity
Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation
Negative Regulation Of Intestinal Epithelial Cell Development
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Mitochondrial tRNA aminoacylation
Drugs
L-Lysine
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Pancreatic cancer (
25086665
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
84 interacting genes:
AIMP2
CDC42
DARS2
DYSF
EEF1D
EEF1G
ESR1
FRS3
GAPDH
GEMIN4
LINC01554
MAPK1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-2
MIR18B
MIR199A1
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR25
MIR29A
MIR29B1
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
PAFAH1B1
PIK3R3
RPSA
SLC25A6
SOD1
SPTAN1
SUMO2
VIM
72 interacting genes:
APOBEC3B
C1QBP
DARS1
DDX1
DDX21
DDX3X
DHX36
EIF2AK2
EPRS1
FAM98A
FUS
G3BP2
HARS2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KNOP1
LARP7
LIN28A
LIN28B
LRPPRC
MARS1
MATR3
MSI1
MSI2
MYEF2
NOL6
NONO
PDCD11
PLOD1
PRMT1
PTBP1
PTBP3
PUF60
PURA
RBFOX2
RBM14
RBM4
RBM47
RBMS2
RTCB
SF3B1
SF3B3
SFPQ
SPOUT1
STRBP
SUGP2
SYNCRIP
TAF15
TRA2A
TRA2B
TRIM25
TRIM71
UPF1
UTP20
YBX1
YBX3
ZFR
ZNF346
Entrez ID
3735
407024
HPRD ID
03249
Ensembl ID
ENSG00000065427
ENSG00000283797
Uniprot IDs
Q15046
PDB IDs
3BJU
4DPG
4YCU
4YCW
6CHD
6ILD
6ILH
Enriched GO Terms of Interacting Partners
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