KLC1 and LRSAM1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KLC1	LRSAM1
Description		kinesin light chain 1	leucine rich repeat and sterile alpha motif containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle	Cytoplasm Cytosol Membrane
	Molecular Function	Motor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Stress Granule Disassembly	Protein Polyubiquitination Autophagy Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)	Mean corpuscular volume ( 32888494)
Interacting Genes		28 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 YWHAB	42 interacting genes: ATXN1 ATXN7 CCDC6 DMAP1 FAM178B GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4
Entrez ID		3831	90678
HPRD ID		02489	14325
Ensembl ID		ENSG00000126214	ENSG00000148356
Uniprot IDs		Q07866 Q7RTQ2	A0A024R870 Q6UWE0
PDB IDs		3NF1 5OJ8
Enriched GO Terms of Interacting Partners?
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