KLC1 and PCM1

Data Source:
BioGRID (two hybrid)

		KLC1	PCM1
Description		kinesin light chain 1	pericentriolar material 1
Image
GO Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Apical Part Of Cell Non-motile Cilium
	Molecular Function	Motor Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Stress Granule Disassembly	G2/M Transition Of Mitotic Cell Cycle Neuron Migration Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Interkinetic Nuclear Migration Cytoplasmic Microtubule Organization Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Ciliary Basal Body-plasma Membrane Docking Non-motile Cilium Assembly
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)	Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)
Interacting Genes		28 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 YWHAB	43 interacting genes: ABI1 ABI2 AKAP9 BBS4 CASK CCDC172 CCHCR1 CDC42 CEP72 CYTH4 DDIT3 DDX23 DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 HAP1 ING5 KLC1 KLC4 KRT15 KRT19 KRT24 MCRS1 NDC80 NECAB2 PCNT PRC1 PRKCI RALBP1 RBM5 RINT1 RPA2 TFIP11 TTC8 WASHC3 YWHAE YWHAQ
Entrez ID		3831	5108
HPRD ID		02489	02624
Ensembl ID		ENSG00000126214	ENSG00000078674
Uniprot IDs		Q07866 Q7RTQ2	A2RUU9 B9EIS5 Q15154
PDB IDs		3NF1 5OJ8	6HYL 6HYM
Enriched GO Terms of Interacting Partners?
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