KLC1 and PLEKHM2

Data Source:
HPRD (in vitro)

		KLC1	PLEKHM2
Description		kinesin light chain 1	pleckstrin homology and RUN domain containing M2
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GO Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle	Endosome Membrane
	Molecular Function	Motor Activity Protein Binding	Protein Binding Kinesin Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Stress Granule Disassembly	Golgi Organization Lysosome Localization Regulation Of Protein Localization Positive Regulation Of Membrane Tubulation
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)	Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		28 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 YWHAB	2 interacting genes: KLC1 SLC39A1
Entrez ID		3831	23207
HPRD ID		02489	11440
Ensembl ID		ENSG00000126214	ENSG00000116786
Uniprot IDs		Q07866 Q7RTQ2	Q5VVD7 Q8IWE5
PDB IDs		3NF1 5OJ8	3CXB 3HW2 3ZFW
Enriched GO Terms of Interacting Partners?
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