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HSD17B13 and VAPB
Data Source:
BioGRID
(two hybrid)
HSD17B13
VAPB
Description
hydroxysteroid 17-beta dehydrogenase 13
VAMP associated protein B and C
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Lipid Droplet
Cytosol
Golgi Membrane
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Membrane
Endoplasmic Reticulum Exit Site
Molecular Function
Molecular_function
Protein Binding
Steroid Dehydrogenase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Protein Binding
Microtubule Binding
Enzyme Binding
FFAT Motif Binding
Protein Homodimerization Activity
Cadherin Binding
Protein Heterodimerization Activity
Beta-tubulin Binding
Biological Process
Lipid Droplet Organization
Positive Regulation Of Lipid Biosynthetic Process
Cellular Calcium Ion Homeostasis
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Endoplasmic Reticulum Organization
Modulation By Virus Of Host Process
Sphingolipid Biosynthetic Process
Endoplasmic Reticulum Unfolded Protein Response
IRE1-mediated Unfolded Protein Response
Positive Regulation Of Viral Genome Replication
Endoplasmic Reticulum-plasma Membrane Tethering
COPII-coated Vesicle Budding
Endoplasmic Reticulum Membrane Organization
Pathways
Lipid particle organization
Sphingolipid de novo biosynthesis
Drugs
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS
Bulimia nervosa (
23568457
)
Liver enzyme levels (alanine transaminase) (
22001757
)
Nonalcoholic steatohepatitis (
32298765
)
Platelet count (
22139419
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
31928498
)
Interacting Genes
118 interacting genes:
ABHD16A
ADGRE2
AGPAT3
AGPAT4
AGTRAP
AIG1
ANKRD46
AOC3
APOA2
ARL6IP1
ATP6V0C
BBC3
BRICD5
C3orf52
CACNG1
CALHM6
CCDC167
CDIPT
CLDN10
CLDN19
CLDN4
CLDND2
CMTM5
CMTM7
CYB5R3
CYBC1
CYP4F2
DIABLO
EBP
ECPAS
FATE1
FAXDC2
FETUB
GJB2
GOLM1
GOSR2
GYPB
HSD3B7
IGFBP5
INSIG2
ITGAM
JAGN1
LPCAT2
LRAT
MARCHF5
MFSD5
MGLL
MIEF2
MMP14
MOSPD3
MS4A1
NAPB
NAT8
NRM
ORMDL3
PBX3
PLIN3
PLN
PLP2
PNLIPRP1
PTPN9
RABAC1
REEP6
RHOU
RPRM
RUSF1
SACM1L
SCAMP5
SCARF1
SCD
SEC22B
SERP1
SFT2D2
SFXN1
SFXN2
SFXN3
SLC25A46
SLC30A3
SLC35B4
SLC35E4
SMIM1
SNORC
SPG21
ST6GAL2
STRIT1
STX5
STX7
TBRG4
TF
THSD7A
TIMM23
TIMMDC1
TMEM100
TMEM120A
TMEM140
TMEM14C
TMEM167B
TMEM19
TMEM203
TMEM222
TMEM229B
TMEM243
TMEM255B
TMEM31
TMEM42
TMEM60
TMEM86B
TMEM97
TMX2
TPRG1
TREX1
UBXN8
UNC50
VAMP2
VAPA
VAPB
YIPF2
YIPF4
41 interacting genes:
AIG1
AQP2
AQP6
CD79A
CYB561
CYBRD1
EBAG9
EBP
ELOVL4
EMD
FAM174A
GLP1R
GPR25
HSD17B13
JAGN1
KCNB1
MTNR1A
OSBPL2
PTGES
REEP4
RETREG3
RMDN2
RNASEK
RNF111
SCN3B
SLC22A1
SLC35C2
STX1A
STX2
STX4
STX5
TMEM101
TMX2
TTC39B
USP20
VAMP1
VAMP2
VHL
VKORC1
ZBTB22
ZDHHC15
Entrez ID
345275
9217
HPRD ID
18023
09300
Ensembl ID
ENSG00000170509
ENSG00000124164
Uniprot IDs
Q7Z5P4
O95292
Q53XM7
PDB IDs
2MDK
3IKK
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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