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HSD17B13 and PLN
Data Source:
BioGRID
(two hybrid)
HSD17B13
PLN
Description
hydroxysteroid 17-beta dehydrogenase 13
phospholamban
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Lipid Droplet
Cytosol
Mitochondrion
Endoplasmic Reticulum
Membrane
Mitochondrial Membrane
Vesicle
Sarcoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Calcium Ion-transporting ATPase Complex
Molecular Function
Molecular_function
Protein Binding
Steroid Dehydrogenase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Enzyme Inhibitor Activity
Protein Binding
ATPase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
ATPase Binding
Biological Process
Lipid Droplet Organization
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of The Force Of Heart Contraction
Calcium Ion Transport
Notch Signaling Pathway
Blood Circulation
Regulation Of Heart Contraction
Response To Zinc Ion
Negative Regulation Of Heart Rate
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Negative Regulation Of ATPase Activity
Response To Insulin
Response To Testosterone
Negative Regulation Of Catalytic Activity
Cardiac Muscle Tissue Development
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Calcium Ion Transport
Negative Regulation Of Calcium Ion Transport
Relaxation Of Cardiac Muscle
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Cardiac Muscle Cell Contraction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process
Regulation Of Cardiac Muscle Cell Membrane Potential
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Binding
Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Regulation Of Relaxation Of Cardiac Muscle
Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways
Lipid particle organization
Ion homeostasis
Ion transport by P-type ATPases
Drugs
Diseases
GWAS
Bulimia nervosa (
23568457
)
Liver enzyme levels (alanine transaminase) (
22001757
)
Nonalcoholic steatohepatitis (
32298765
)
Platelet count (
22139419
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
31928498
)
Atrial fibrillation (
28416818
30061737
)
Cardiac structure and function (
19584346
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
27659466
)
QT interval (
23166209
24952745
19305408
19305409
19587794
29874175
)
Resting heart rate (
27798624
)
Interacting Genes
118 interacting genes:
ABHD16A
ADGRE2
AGPAT3
AGPAT4
AGTRAP
AIG1
ANKRD46
AOC3
APOA2
ARL6IP1
ATP6V0C
BBC3
BRICD5
C3orf52
CACNG1
CALHM6
CCDC167
CDIPT
CLDN10
CLDN19
CLDN4
CLDND2
CMTM5
CMTM7
CYB5R3
CYBC1
CYP4F2
DIABLO
EBP
ECPAS
FATE1
FAXDC2
FETUB
GJB2
GOLM1
GOSR2
GYPB
HSD3B7
IGFBP5
INSIG2
ITGAM
JAGN1
LPCAT2
LRAT
MARCHF5
MFSD5
MGLL
MIEF2
MMP14
MOSPD3
MS4A1
NAPB
NAT8
NRM
ORMDL3
PBX3
PLIN3
PLN
PLP2
PNLIPRP1
PTPN9
RABAC1
REEP6
RHOU
RPRM
RUSF1
SACM1L
SCAMP5
SCARF1
SCD
SEC22B
SERP1
SFT2D2
SFXN1
SFXN2
SFXN3
SLC25A46
SLC30A3
SLC35B4
SLC35E4
SMIM1
SNORC
SPG21
ST6GAL2
STRIT1
STX5
STX7
TBRG4
TF
THSD7A
TIMM23
TIMMDC1
TMEM100
TMEM120A
TMEM140
TMEM14C
TMEM167B
TMEM19
TMEM203
TMEM222
TMEM229B
TMEM243
TMEM255B
TMEM31
TMEM42
TMEM60
TMEM86B
TMEM97
TMX2
TPRG1
TREX1
UBXN8
UNC50
VAMP2
VAPA
VAPB
YIPF2
YIPF4
64 interacting genes:
ARL13B
ASGR2
ATP2A1
ATP2A2
ATP6V0E1
BCL2L13
BIK
CD53
CLDN7
CLEC2D
CPLX4
CREB3
CREB3L1
DMPK
DVL3
EDA
ELOVL4
FAM209A
FKBP8
FNDC9
GJA8
GPR152
GPR37L1
GPX8
HIBADH
HSD17B13
KIR2DL3
LDLRAD1
LSMEM2
MFF
MFSD5
MGST2
MGST3
MS4A7
MTIF3
MUC1
PLPPR1
PPP1R3A
PRKACA
RTN3
S100A1
SAR1A
SDC3
SIT1
SLC14A2
SLC30A8
SLC34A2
SLC35C2
SLC39A2
SLN
SPACA1
SPAG4
STX1A
STX2
TMEM106C
TMEM179B
TMEM205
TMEM31
TMEM45A
TMEM45B
TMEM52B
TMEM79
TMEM86B
TMPRSS2
Entrez ID
345275
5350
HPRD ID
18023
01395
Ensembl ID
ENSG00000170509
ENSG00000198523
Uniprot IDs
Q7Z5P4
P26678
Q5R352
PDB IDs
1K9N
1KCH
1PLN
1PLP
1PSL
1ZLL
2HYN
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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