CXXC1 and NR5A1

Data Source:
BioGRID (two hybrid)

		CXXC1	NR5A1
Description		CXXC finger protein 1	nuclear receptor subfamily 5 group A member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated IRE1-mediated Unfolded Protein Response Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation	Luteinization Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development
Pathways		XBP1(S) activates chaperone genes	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation
Drugs			(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases			Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronic lymphocytic leukemia ( 28165464)	Chronotype ( 30696823)
Interacting Genes		9 interacting genes: EP300 MEOX2 NR5A1 PPP1CA SMURF1 TAX1BP1 TBP TCP11L2 TP53	35 interacting genes: AR C2CD6 CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653
Entrez ID		30827	2516
HPRD ID		10852	01702
Ensembl ID		ENSG00000154832	ENSG00000136931
Uniprot IDs		Q9P0U4	F1D8R8 Q13285
PDB IDs		3QMB 3QMC 3QMD 3QMG 3QMH 3QMI	1YOW 1ZDT 4QJR 4QK4
Enriched GO Terms of Interacting Partners?
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