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NR5A1 and SOX9
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
NR5A1
SOX9
Description
nuclear receptor subfamily 5 group A member 1
SRY-box transcription factor 9
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Protein-containing Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Nuclear Receptor Activity
Protein Binding
Phospholipid Binding
Zinc Ion Binding
Enzyme Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Protein Kinase A Catalytic Subunit Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Pre-mRNA Intronic Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Luteinization
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Sex Determination
Primary Sex Determination
Male Gonad Development
Female Gonad Development
Hormone-mediated Signaling Pathway
Tissue Development
Multicellular Organism Aging
Positive Regulation Of Gene Expression
Cell Differentiation
Male Sex Determination
Adrenal Gland Development
Intracellular Receptor Signaling Pathway
Hormone Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Steroid Biosynthetic Process
Maintenance Of Protein Location In Nucleus
Response To Gonadotropin-releasing Hormone
Calcineurin-mediated Signaling
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Cartilage Condensation
Ossification
Branching Involved In Ureteric Bud Morphogenesis
Cell Fate Specification
Epithelial To Mesenchymal Transition
Tissue Homeostasis
Positive Regulation Of Protein Phosphorylation
Hair Follicle Development
Morphogenesis Of An Epithelium
Positive Regulation Of Mesenchymal Cell Proliferation
Chondrocyte Differentiation
Negative Regulation Of Immune System Process
Heart Valve Development
Heart Valve Morphogenesis
Aortic Valve Morphogenesis
Heart Valve Formation
Endocardial Cushion Morphogenesis
Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
Chondrocyte Hypertrophy
Growth Plate Cartilage Chondrocyte Growth
Nucleosome Assembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Cytoskeleton Organization
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Notch Signaling Pathway
Spermatogenesis
Heart Development
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Regulation Of Cell Cycle Process
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Neural Crest Cell Development
Neural Crest Cell Fate Specification
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Male Germ-line Sex Determination
CAMP-mediated Signaling
Regulation Of Cell Adhesion
Extracellular Matrix Organization
Negative Regulation Of Ossification
Negative Regulation Of Bone Mineralization
Prostate Gland Development
Negative Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
Notochord Development
Otic Vesicle Formation
Endocrine Pancreas Development
Negative Regulation Of Chondrocyte Differentiation
Positive Regulation Of Chondrocyte Differentiation
Lacrimal Gland Development
Protein Localization To Nucleus
Somatic Stem Cell Population Maintenance
Intrahepatic Bile Duct Development
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Fatty Acid Oxidation
Negative Regulation Of Photoreceptor Cell Differentiation
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Cartilage Development
Sertoli Cell Differentiation
Sertoli Cell Development
Astrocyte Fate Commitment
Retina Development In Camera-type Eye
Limb Bud Formation
Retinal Rod Cell Differentiation
Epithelial Tube Branching Involved In Lung Morphogenesis
Lung Epithelial Cell Differentiation
Epithelial Cell Proliferation Involved In Prostatic Bud Elongation
Bronchus Cartilage Development
Trachea Cartilage Development
Intestinal Epithelial Structure Maintenance
Regulation Of Cell Proliferation Involved In Tissue Homeostasis
Positive Regulation Of Cartilage Development
Regulation Of Branching Involved In Lung Morphogenesis
Morphogenesis Of A Branching Epithelium
Lung Smooth Muscle Development
Protein-containing Complex Assembly
Negative Regulation Of Biomineral Tissue Development
ERK1 And ERK2 Cascade
Harderian Gland Development
Response To Fatty Acid
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Interleukin-1
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Heparin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Renal Vesicle Induction
Ureter Urothelium Development
Ureter Smooth Muscle Cell Differentiation
Ureter Morphogenesis
Metanephric Nephron Tubule Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Positive Regulation Of Kidney Development
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Anterior Head Development
Cell-cell Adhesion
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Chondrocyte Proliferation
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Beta-catenin-TCF Complex Assembly
Positive Regulation Of Male Gonad Development
Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Positive Regulation Of Mesenchymal Stem Cell Differentiation
Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Transcriptional regulation of pluripotent stem cells
Transcriptional regulation of testis differentiation
Deactivation of the beta-catenin transactivating complex
Transcriptional regulation by RUNX2
Transcriptional regulation of testis differentiation
Drugs
(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE
Phosphatidyl ethanol
Diseases
Premature ovarian failure
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
Campomelic dysplasia (CD)
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Chronotype (
30696823
)
Adolescent idiopathic scoliosis (severe) (
24023777
)
Cervical cancer (
31488892
)
Cervical cancer (MTAG) (
31488892
)
Chin dimples (
27182965
)
Chronic obstructive pulmonary disease (
30804561
)
Coronary artery calcification (
23870195
)
Facial morphology (
31763980
)
Femoral neck bone mineral density (
22504420
)
Fractures (paediatric) (
32742401
)
Gynecologic disease (multivariate analysis) (
31488892
)
Hip bone size (
31053729
)
Hyperthyroidism (
30367059
)
Intertrochanteric region size (
31053729
)
Kidney stones (
31729369
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Lung adenocarcinoma (
28604730
)
Lung cancer (
28604730
)
Nose morphology (
29921221
)
Nose size (
27182965
)
Prostate cancer (
24753544
)
Pulmonary function (smoking interaction) (
23284291
)
Pulmonary function decline (
22424883
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Thyrotoxic hypokalemic periodic paralysis and Graves disease (
31050781
)
Interacting Genes
35 interacting genes:
AR
C2CD6
CKS1B
CREBBP
CTNNB1
CXXC1
EDF1
GATA4
GTF2B
JUN
MAPK1
NCK2
NCOA1
NFKB2
NFYA
NR0B1
NRIP1
NTAQ1
PIAS1
PITX1
PNRC2
PROX1
RAD54L2
RFC5
SMARCD3
SOX2
SOX8
SOX9
SP1
TBX19
TEKT4
TRAPPC2
TRERF1
UBE2I
ZNF653
17 interacting genes:
ATP6V1H
CREB1
CREB3L4
CREBBP
ELF3
EP300
FBXW7
HERC1
HSPA1A
KPNB1
MAF
MED12
NR5A1
RUNX2
SPEN
TRAF2
UBE2I
Entrez ID
2516
6662
HPRD ID
01702
06427
Ensembl ID
ENSG00000136931
ENSG00000125398
Uniprot IDs
F1D8R8
Q13285
P48436
PDB IDs
1YOW
1ZDT
4QJR
4QK4
1S9M
1SX9
4EUW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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