NR5A1 and SOX8

Data Source:
HPRD (in vitro)

		NR5A1	SOX8
Description		nuclear receptor subfamily 5 group A member 1	SRY-box transcription factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Luteinization Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Regulation Of Transcription By RNA Polymerase II Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Neural Crest Cell Development Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Logical memory (immediate recall) in normal cognition ( 29274321) Multiple sclerosis ( 31604244 21833088) Polycystic ovary syndrome ( 25574032)
Interacting Genes		35 interacting genes: AR C2CD6 CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653	18 interacting genes: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		2516	30812
HPRD ID		01702	16175
Ensembl ID		ENSG00000136931	ENSG00000005513
Uniprot IDs		F1D8R8 Q13285	P57073
PDB IDs		1YOW 1ZDT 4QJR 4QK4
Enriched GO Terms of Interacting Partners?
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