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NR5A1 and PITX1
Data Source:
HPRD
(in vitro)
NR5A1
PITX1
Description
nuclear receptor subfamily 5 group A member 1
paired like homeodomain 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Nuclear Receptor Activity
Protein Binding
Phospholipid Binding
Zinc Ion Binding
Enzyme Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Luteinization
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Sex Determination
Primary Sex Determination
Male Gonad Development
Female Gonad Development
Hormone-mediated Signaling Pathway
Tissue Development
Multicellular Organism Aging
Positive Regulation Of Gene Expression
Cell Differentiation
Male Sex Determination
Adrenal Gland Development
Intracellular Receptor Signaling Pathway
Hormone Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Steroid Biosynthetic Process
Maintenance Of Protein Location In Nucleus
Response To Gonadotropin-releasing Hormone
Calcineurin-mediated Signaling
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Skeletal System Development
Regulation Of Transcription By RNA Polymerase II
Anatomical Structure Morphogenesis
Branchiomeric Skeletal Muscle Development
Pituitary Gland Development
Embryonic Hindlimb Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Myoblast Fate Commitment
Cartilage Development
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Transcriptional regulation of pluripotent stem cells
Transcriptional regulation of testis differentiation
Drugs
(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE
Phosphatidyl ethanol
Diseases
Premature ovarian failure
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
Congenital clubfoot; Congenital talipes equinovarus
GWAS
Chronotype (
30696823
)
Atrial fibrillation (
29237688
)
Bulimia nervosa (
23568457
)
Colorectal cancer (
30529582
24836286
23263487
)
Colorectal cancer or advanced adenoma (
30510241
)
Height (
20881960
25429064
23563607
31562340
18391951
)
Immune response to anthrax vaccine (
22658931
)
Testicular germ cell tumor (
28604732
23666240
)
Interacting Genes
35 interacting genes:
AR
C2CD6
CKS1B
CREBBP
CTNNB1
CXXC1
EDF1
GATA4
GTF2B
JUN
MAPK1
NCK2
NCOA1
NFKB2
NFYA
NR0B1
NRIP1
NTAQ1
PIAS1
PITX1
PNRC2
PROX1
RAD54L2
RFC5
SMARCD3
SOX2
SOX8
SOX9
SP1
TBX19
TEKT4
TRAPPC2
TRERF1
UBE2I
ZNF653
98 interacting genes:
ABHD11
AKAP8L
ALG13
ANKRD10
ARID5A
ATN1
BPIFA1
C10orf55
C11orf1
C19orf54
C1orf94
C9orf57
CDX4
CEACAM6
CYSRT1
DCTN3
DVL3
DZIP3
EFEMP2
EGR1
FAM168A
FAM168B
FOXO1
GATA1
GOLGA2
HGS
HOXA1
HSF4
HYI
IGFL2
IPO13
KLHL26
KRT34
KRT83
KRTAP13-1
KRTAP13-2
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
LASP1
LZTS2
MAGED1
METTL27
MGAT5B
MSX2
MYH7B
MYOZ3
NEUROD1
NHLRC4
NID2
NR5A1
PFDN5
PLA2G10
PLEKHB2
PLSCR1
PLSCR3
POU1F1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMB11
PTK6
RBPMS
RFX6
RHOXF2
RNF31
ROR2
SERGEF
SERPINE1
SIK1B
SLC15A2
SMARCA2
SPAG8
STH
TBX19
TBX22
TEKT5
TFAP2D
TLE5
TP53BP1
TRAF1
TRAPPC2
TRIM23
TSC1
UFSP1
UPF2
VGLL3
YPEL3
ZBTB32
ZNF34
Entrez ID
2516
5307
HPRD ID
01702
03688
Ensembl ID
ENSG00000136931
ENSG00000069011
Uniprot IDs
F1D8R8
Q13285
P78337
X5D9A5
PDB IDs
1YOW
1ZDT
4QJR
4QK4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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