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NR5A1 and EDF1
Data Source:
HPRD
(in vitro, in vivo)
NR5A1
EDF1
Description
nuclear receptor subfamily 5 group A member 1
endothelial differentiation related factor 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Intracellular Anatomical Structure
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Nuclear Receptor Activity
Protein Binding
Phospholipid Binding
Zinc Ion Binding
Enzyme Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
TFIID-class Transcription Factor Complex Binding
DNA Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
Calmodulin Binding
Biological Process
Luteinization
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Sex Determination
Primary Sex Determination
Male Gonad Development
Female Gonad Development
Hormone-mediated Signaling Pathway
Tissue Development
Multicellular Organism Aging
Positive Regulation Of Gene Expression
Cell Differentiation
Male Sex Determination
Adrenal Gland Development
Intracellular Receptor Signaling Pathway
Hormone Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Steroid Biosynthetic Process
Maintenance Of Protein Location In Nucleus
Response To Gonadotropin-releasing Hormone
Calcineurin-mediated Signaling
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Regulation Of Transcription, DNA-templated
Multicellular Organism Development
Regulation Of Lipid Metabolic Process
Positive Regulation Of DNA Binding
Endothelial Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Transcriptional regulation of pluripotent stem cells
Transcriptional regulation of testis differentiation
Drugs
(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE
Phosphatidyl ethanol
Diseases
Premature ovarian failure
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Chronotype (
30696823
)
Interacting Genes
35 interacting genes:
AR
C2CD6
CKS1B
CREBBP
CTNNB1
CXXC1
EDF1
GATA4
GTF2B
JUN
MAPK1
NCK2
NCOA1
NFKB2
NFYA
NR0B1
NRIP1
NTAQ1
PIAS1
PITX1
PNRC2
PROX1
RAD54L2
RFC5
SMARCD3
SOX2
SOX8
SOX9
SP1
TBX19
TEKT4
TRAPPC2
TRERF1
UBE2I
ZNF653
22 interacting genes:
ATF1
ATF2
CALM1
CALM2
CALM3
CDC42
CEBPA
CREB1
JUN
MAPK6
MEOX2
NR1H3
NR5A1
NR5A2
NRL
PPARG
PRKCA
RXRA
SOX4
TAF1
TBP
UBE2I
Entrez ID
2516
8721
HPRD ID
01702
09235
Ensembl ID
ENSG00000136931
ENSG00000107223
Uniprot IDs
F1D8R8
Q13285
O60869
PDB IDs
1YOW
1ZDT
4QJR
4QK4
1X57
6ZVH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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