HEXA and USP22

Data Source:
BioGRID (two hybrid)

		HEXA	USP22
Description		hexosaminidase subunit alpha	ubiquitin specific peptidase 22
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Azurophil Granule Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome	SAGA Complex Nucleoplasm SAGA-type Complex
	Molecular Function	Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Protein Heterodimerization Activity N-acetyl-beta-D-galactosaminidase Activity	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Coactivator Activity
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Chondroitin Sulfate Catabolic Process Hyaluronan Catabolic Process Keratan Sulfate Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle
Pathways		Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXA causes GM2G1	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS			Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		2 interacting genes: GM2A USP22	17 interacting genes: AASDHPPT ATXN7 ATXN7L3 BAG4 CD274 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MTUS2 MYC PSME1 PTGS2 RCAN1 SCFD1 UBC
Entrez ID		3073	23326
HPRD ID		06040	19411
Ensembl ID		ENSG00000213614	ENSG00000124422
Uniprot IDs		A0A0S2Z3W3 B4DVA7 H3BP20 P06865	Q9UPT9
PDB IDs		1QBC 2GJX 2GK1
Enriched GO Terms of Interacting Partners?
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